Thiamine hydrochloride is the hydrochloride of thiamine, also known as thiamine. It is the earliest water-soluble vitamin purified by people. Its chemical formula is C12H17ClN4OS·HCl. It is a form of vitamin B1.
It has the function of maintaining normal glucose metabolism, and is often used clinically to prevent and treat beriberi caused by lack of VB1.
As a nutritional supplement.
Vitamin B1 participates in the intermediate metabolism of carbohydrates in the body.
Insufficient vitamin B1 in the body, cocarboxylase activity decreases, glucose metabolism is blocked, thus affecting the entire body's metabolic process.
Insufficient vitamin B1 can also cause symptoms such as indigestion, loss of appetite and constipation.
| Appearance | White crystal or crystalline powder | < 0.5kg/mg |
| Infrared Absorption | Consistent with the reference IR spectra | Consistent with the reference IR spectra |
| Chloride | A white curdy precipitate is formed with silver nitrate, the precipitate is insoluble on nitric acid, but dissolves readily in ammonia | A white curdy precipitate is formed with silver nitrate, the precipitate is insoluble on nitric acid, but dissolves readily in ammonia |
| Appearance of Solution | Clear, not more intense than Y 7 or GY 7 | Clear, not more intense than Y 7 |
| Water | ≤ 5.0% | 2.81% |
| Sulphates | ≤ 0.03% | < 0.03% |
| Residue on Ignition | ≤ 0.1% | 0.02% |
| Absorbance of Solution | ≤ 0.025% | 0.020% |
| Limit of Nitrate | No brown ring is produced at the junction of the two layers | No brown ring is produced at the junction of the two layers |
| Impurity A | ≤ 0.15% | Comply |
| Impurity B | ≤ 0.3% | Comply |
| Impurity C | ≤ 0.15% | Comply |
| Unspecified Impurity | ≤ 0.10% | Comply |
| Total Impurity | ≤ 0.5% | Comply |
| Methanol | ≤ 0.3% | GC, In-house |
| Ethanol | ≤ 0.5% | GC, In-house |
| Related Compounds | ≤ 1.0% | 0.04% |
| Lead | ≤ 0.5kg/mg | < 0.5kg/mg |
| Cadmium | ≤ 0.5kg/mg | < 0.5kg/mg |
| Arsenic | ≤ 0.5kg/mg | < 0.5kg/mg |
| Mercury | ≤ 0.1kg/mg | < 0.1kg/mg |
| PH Value | 2.7 - 3.3 | 3.2 |
| Assay (on anhydrous basis) | 98.0% ~ 102.0% | 99.5% |
| Total Plate Count | ≤ 100cfu/g | < 100cfu/g |
| Yeast & Mold | ≤ 10cfu/g | < 10cfu/g |
| E. Coli | Negative | Negative |
| Salmonella | Negative | Negative |
| S. Aureus | Negative | Negative |
| Residue on Ignition | ≤ 0.2% | 0.01% |
| Chloride | ≤ 0.06% | < 0.06% |
| Related Compounds | ≤ 1.0% | 0.24% |
|
Residual Solvent-
Methanol |
≤ 0.3% | 0.0018% |
| PH Value | 6.0-7.5 | 7.2 |
| Assay | 98.0% ~ 102.0% | 99.3% |
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