Wholesale Urolithin a in Good Price CAS 1143-70-0

Model NO.
1143-70-0
Colour
Yellow
Category.
Reference Substance
Category..
Biological Reagent
Category
Raw Materials for Medical and Health Care Products
MOQ
1kg
Transport Package
Bag/Drum
Specification
1kg/bag, 25kg/Drum
Trademark
Xingjiu
Origin
China
Production Capacity
200tons/Year
Reference Price
Please contact us for quote
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Product Description

Product Description
 
Wholesale Urolithin a in Good Price CAS 1143-70-0
Wholesale Urolithin a in Good Price CAS 1143-70-0
 

    

" 3, 8-dihydroxy-6H-dibenzoic [B,D] pyran-6-one is also known as urolithin A." Studies have reported that A substance in pomegranates and other fruits called UrolithinA may help slow down the chemicalbookspecific aging process by improving the function of mitochondria in cells; Furthermore, there is no risk to human health from ingestion of this compound. It has been shown that urolycitin A stimulates mitochondrial biogenesis in a manner similar to regular exercise and is the only compound that reconstitutes cellular recycling of defective mitochondria.
     Urolithin A, the gut microbial metabolite of ellagic acid, has anti-inflammatory, anti-proliferative, and anti-oxidative properties. Urolithin A induces autophagy and apoptosis, inhibits cell cycle progression, and inhibits DNA synthesis.


MicromolarurolithinAconcentrationsinducesbothautophagyandapoptosis.UrolithinAsuppressescellcycleprogressionandinhibitedDNAsynthesisinhumansw620colorectalcancercells.UrolithinAshowsantiproliferativeeffectsandinhibitsT24andCaco-2cellgrowthwithIC50sof43.9and49μM,respectively.UrolithinAexertsadose-andtime-dependentsignificantarrestatG2/MandSphasesaftertreatmentswith50and100μMat24and48hcomparChemicalbookedtocontrolcells.Itinducescellapoptosiswith50and100μM.UrolithinAshowspotentantiproliferativeactivityonHepG2cells.WhencelldeathisinducedbyUrolithinA,theexpressionofβ-catenin,c-MycandCyclinD1aredecreasedandTCF/LEFtranscriptionalactivationisnotablydown-regulated.UrolithinAalsoincreasesproteinexpressionofp53,p38-MAPKandcaspase-3,butsuppressesexpressionofNF-κBp65andotherinflammatorymediators.
Wholesale Urolithin a in Good Price CAS 1143-70-0 Wholesale Urolithin a in Good Price CAS 1143-70-0 Wholesale Urolithin a in Good Price CAS 1143-70-0

Wholesale Urolithin a in Good Price CAS 1143-70-0 Wholesale Urolithin a in Good Price CAS 1143-70-0

FAQ

Q 1: Are you a manufacturer?
A:   Yes, we are factory located in H e bei province.

Q2: Do you accept sample orders?
A:   Yes,we welcome sample orders to test and check our product quality. 
      Your reliance is the first step of our cooperation.

Q 3 : What kind terms of payment can be accepted?
     A:  T/T, West Union, L/C ,  Money Gram accepted
      30% T/T advance payment as deposit, 70% balance payment when the order is ready for shipment.

Q 4 : Which information in the inquiry you should send us?
A:   Chemical name/   CAS No ./exact quantity/ usage or field/destination port/other special requirements.

Q 5 : Is there any discount?
A: Yes. The price is negotiable.   It depend on your qty .

Q 6 :How long does it take to the goods arrived?
A:For 1KG-100KG, Within 5-7 days by DHL,UPS,TNT, FEDEX,EMS    
Over 100KG.within 5-8days by air,20-40days by sea. usually shipping by DHL, Fedex, EMS, TNT, HKETK.

Q7: How do you treat quality complaint?
A:   First of all,our quality control will reduce the quality problem to near zero. If there is a real quality problem caused by us, we will send you free goods for replacement or refund your loss.

 

Organic Intermediate

PNEUTEC.IT, 2023