Nutritional Supplements Nmn Beta Nicotinamide Mononucleotide CAS 1094-61-7
Model NO.
1094-61-7
Trademark
Na
Origin
China
HS Code
2934
Production Capacity
5, 000, 000kg/Year
Reference Price
$ 121.50 - 135.00
Description
Product Description
Product Name β-Nicotinamide Mononucleotide
Alias NMN
Molecular Formula C11H15N2O8P
Molecular Weight 334.2192
CAS No. 1094-61-7
Shelf Life 2 years
Quality Standard In-house
Specification:
Brief introduction
Nicotinamide mononucleotide, also known as β- Nicotinamide mononucleotide (NMN) is a synthetic substrate for coenzyme I, and NMN is also used in anti-aging research. Research has shown that, β- NMN can also regulate insulin secretion and affect mRNA expression levels, β- NMN has broad application prospects in the field of medical treatment.
β- Nicotinamide mononucleotides are products of extracellular nicotinamide phosphoribosyltransferase (eNAMPT) reactions and key NAD+intermediates. It improves glucose tolerance by restoring NAD+levels in HFD induced T2D mice. It also enhances insulin sensitivity in the liver and partially restores gene expression related to oxidative stress, inflammatory response and circadian rhythm through SIRT1 activation.
Purpose
In mammals, β- Nicotinamide mononucleotides are generated by nicotinamide (Nam) under the catalysis of Nampt (a protease in vivo), followed by NAD+production under the catalysis of nicotinamide mononucleotide adenosine transferase. Nicotinamide mononucleotides are a direct way to supplement NAD+. Nicotinamide mononucleotides significantly enhance the repair ability of intracellular DNA damage, ultimately achieving the effect of reversing aging.
Nicotinamide mononucleotides are converted into essential "nicotinamide adenine dinucleotide (NAD)" substances for energy metabolism in the body. In mouse experiments, it was confirmed that nicotinamide mononucleotide can activate a gene called acetylase in the body, so as to play a role in prolonging life and treating diabetes. NAD is a substance that the human body could originally generate, and research has confirmed that the content of NAD in the body decreases with age.
Application
β- Nicotinamide mononucleotide is the precursor of cofactor NAD+of longevity protein in human body. NAD+is an important coenzyme in the tricarboxylic acid cycle, promoting the metabolism of sugars, fats, and amino acids, and participating in energy synthesis; NAD+is the only substrate for CoI consuming enzymes (the only substrate for DNA repair enzyme PARP, the only substrate for longevity protein Sirtuins, and the only substrate for cyclic ADP ribose synthase CD38/157).
NAD+participates in all aspects of human metabolism and is a key coenzyme. Without NAD+, metabolism cannot function properly. Elderly people lack NAD+, leading to various problems of varying sizes. By supplementing with NAD+, they can comprehensively combat aging.
Pre clinical studies have shown that NMN has a variety of pharmacological activities in heart and brain ischemia, Alzheimer's disease, type 2 diabetes and obesity caused by diet and age. As a prodrug of NAD+, NMN mainly synthesizes NAD+in vivo to play a pharmacological role, all of which are related to the lack of NAD+.
Packing:
1Kg/bag, 25Kg/carton
Storage:
Store in tightly closed original container, protected from light, in a dry place.
Alias NMN
Molecular Formula C11H15N2O8P
Molecular Weight 334.2192
CAS No. 1094-61-7
Shelf Life 2 years
Quality Standard In-house
Specification:
| Analytical Items | Standard | |
| Appearance | White to off-white powder | |
| Identification | HPLC | |
| Loss on drying | ≤5.0% | |
| Sodium | ≤1.0% | |
| Heavy Metals (Pb) | ≤0.5PPm | |
| As | ≤0.5PPm | |
| Cd | ≤0.5PPm | |
| Hg | ≤0.1PPm | |
| Residual sulvent (Ethanol) | ≤2.0% | |
| Assay (HPLC) | 99.0%~101.0% | |
| Microbial limit test | ||
| Total aerobicbacteria count | ≤1000cfu/g | |
| Mold and yeast count | ≤100cfu/g | |
| Escherichia coli | Negative | |
| Salmonella | Negative | |
| Staphylococcus aureus | Negative | |
Brief introduction
Nicotinamide mononucleotide, also known as β- Nicotinamide mononucleotide (NMN) is a synthetic substrate for coenzyme I, and NMN is also used in anti-aging research. Research has shown that, β- NMN can also regulate insulin secretion and affect mRNA expression levels, β- NMN has broad application prospects in the field of medical treatment.
β- Nicotinamide mononucleotides are products of extracellular nicotinamide phosphoribosyltransferase (eNAMPT) reactions and key NAD+intermediates. It improves glucose tolerance by restoring NAD+levels in HFD induced T2D mice. It also enhances insulin sensitivity in the liver and partially restores gene expression related to oxidative stress, inflammatory response and circadian rhythm through SIRT1 activation.
Purpose
In mammals, β- Nicotinamide mononucleotides are generated by nicotinamide (Nam) under the catalysis of Nampt (a protease in vivo), followed by NAD+production under the catalysis of nicotinamide mononucleotide adenosine transferase. Nicotinamide mononucleotides are a direct way to supplement NAD+. Nicotinamide mononucleotides significantly enhance the repair ability of intracellular DNA damage, ultimately achieving the effect of reversing aging.
Nicotinamide mononucleotides are converted into essential "nicotinamide adenine dinucleotide (NAD)" substances for energy metabolism in the body. In mouse experiments, it was confirmed that nicotinamide mononucleotide can activate a gene called acetylase in the body, so as to play a role in prolonging life and treating diabetes. NAD is a substance that the human body could originally generate, and research has confirmed that the content of NAD in the body decreases with age.
Application
β- Nicotinamide mononucleotide is the precursor of cofactor NAD+of longevity protein in human body. NAD+is an important coenzyme in the tricarboxylic acid cycle, promoting the metabolism of sugars, fats, and amino acids, and participating in energy synthesis; NAD+is the only substrate for CoI consuming enzymes (the only substrate for DNA repair enzyme PARP, the only substrate for longevity protein Sirtuins, and the only substrate for cyclic ADP ribose synthase CD38/157).
NAD+participates in all aspects of human metabolism and is a key coenzyme. Without NAD+, metabolism cannot function properly. Elderly people lack NAD+, leading to various problems of varying sizes. By supplementing with NAD+, they can comprehensively combat aging.
Pre clinical studies have shown that NMN has a variety of pharmacological activities in heart and brain ischemia, Alzheimer's disease, type 2 diabetes and obesity caused by diet and age. As a prodrug of NAD+, NMN mainly synthesizes NAD+in vivo to play a pharmacological role, all of which are related to the lack of NAD+.
Packing:
1Kg/bag, 25Kg/carton
Storage:
Store in tightly closed original container, protected from light, in a dry place.
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