Pharmaceutical Raw Material Powder Aprepitant CAS 170729-80-3 for antiemetic in high quality 99%

Identification
Name	Aprepitant
Structure
Other names	Aponvie Cinvanti L-754,030 aprepitantum 5-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl]-1,2-dihydro-1,2,4-triazol-3-one 3-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl]-1,4-dihydro-1,2,4-triazol-5-one 5-[[(2R,3S)-2-[(1R)-1-[3,5-BIS(Trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-3H-1,2,4-triazol-3-one
Keywords	Cancer Antiemetics Antinauseants antagonist Pharmaceutical material Inhibitors Intermediates & Fine Chemicals Pharmaceuticals pharmaceutical intermediate Active Pharmaceutical Ingredients API's
CAS NO.	170729-80-3
Molecular Formula	C23H21F7N4O3
Molecular Weight	534.43 g/mol
Chemical and Physical Properties
Appearance	White to beige powder
Solubility	Soluble in DMSO (>25 mg/ml)
Melting point	244-246°C
Quality standard	99%
Application
Drug Indication/Application/Use	Aprepitant is a morpholine-based antiemetic, which is or the prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of highly emetogenic cancer chemotherapy. Aprepitant is a selective high-affinity antagonist of human substance P/neurokinin 1 (NK1) receptors. It has a role as an antidepressant, an antiemetic, a peripheral nervous system drug, a neurokinin-1 receptor antagonist and a substance P receptor antagonist.
Formulations/Preparations	Oral
Handling and Storage
Safety and Hazards	The shanghai Research Institute of Chemical industry testing center identification conclusion :1 None hazard identification, 2 The substance is not subject to IATA DGR, 3 Non packing requirements.
Handling and Storage	Sealed in dry,2-8°C
Sample package	Double plastic bags inside, aluminium foil bag outside.
Commercial package	Double plastic bags inside,5kg, 10kg, 25kg fiber drum outside.
UN Code	Not classified
HS Code	2942000000
Shipping group	Shipment at ambient temperature for no controlled and no dangerous goods
Sales restriction	No
Origin	China
Technnical support
STD Data sheet	Yes
MSDS	Yes
COA	Yes
Transport certificate	Yes
Supply ability
Monthly capacity	100kg a month
GMP	N/A

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