Safe Shipping 99% Etomidate Reached Safely From China Factory 33125-97-2
Model NO.
33125-97-2
Delivery Time
7-10 Days
MOQ
1kg
Shipping Method
FedEx, DHL, TNT, UPS
Sample
Avaliable
Transport Package
25kg
Specification
1kg
Trademark
Dujiang
Origin
Hubei, China
HS Code
29332900
Production Capacity
5000tons/Year
Reference Price
$ 27.00 - 45.00
Description
Product Description
| Etomidate Basic information |
| Product Name: | Etomidate |
| Synonyms: | (r)-(+)-1-(alpha-methylbenzyl)imidazole-5-carboxylicacidethylester;1-(1-phenylethyl)-,ethylester,(r)-1h-imidazole-5-carboxylicaci;1-(1-Phenylethyl)-1H-imidazole-5-carboxylic acid ethyl ester;1-(1-phenylethyl)-1h-imidazole-5-carboxylicacidethylester;Amidate, R16659;Imidazole-5-carboxylic acid, 1-(alpha-methylbenzyl)-, ethyl ester, (R)-(+);1-[(R)-α-Methylbenzyl]-1H-imidazole-5-carboxylic acid ethyl ester;Etomidate (200 mg) |
| CAS: | 33125-97-2 |
| MF: | C14H16N2O2 |
| MW: | 244.29 |
| EINECS: | 251-385-9 |
| Etomidate Chemical Properties |
| Melting point | 72-74°C |
| alpha | D20 +66° (c = 1 in ethanol) |
| Boiling point | 160-162 °C(Press: 1 Torr) |
| density | 1.11±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: >10 mg/mL |
| form | powder |
| pka | pKa 4.24(H2O t=25.0) (Uncertain) |
| color | white |
| Merck | 14,3881 |
| CAS DataBase Reference | 33125-97-2(CAS DataBase Reference) |
| NIST Chemistry Reference | Etomidate(33125-97-2) |
| Etomidate Usage And Synthesis |
| Chemical Properties | Etomidate is a white crystalline powder. easily soluble in water, methanol, ethanol and propylene glycol, soluble in chloroform, insoluble in acetone, insoluble in ether. Its effects on the central nervous system is similar to barbiturates. |
| Originator | Hypnomidate,Janssen,W. Germany,1977 |
| Uses | Etomidate is a GABAA receptors agonist with short-acting sedative, hypnotic, and general anesthetic properties. It is a unique drug used for induction of general anesthesia and sedation. It is also a hypnotic. Hypnotic effect of Etomidate is strong , and its efficacy is about 12 times higher than thiopental, it has no analgesic effect. |
| Definition | ChEBI: Etomidate is the ethyl ester of 1-[(1R)-1-phenylethyl]-1H-imidazole-5-carboxylic acid. It is an intravenous general anaesthetic with no analgesic activity. It has a role as an intravenous anaesthetic and a sedative. It is a member of imidazoles and an ethyl ester. It derives from a 1-[(1R)-1-phenylethyl]-1H-imidazole-5-carboxylic acid. |
| Brand name | Amidate (Hospira);Hypnomidate concentrate;Hypnomidate injection;Hypromidate;Nalgol;Sibu. |
| Therapeutic Function | Hypnotic |
| World Health Organization (WHO) | Etomidate, a potent hypnotic agent, was introduced in 1977 for use as an intravenous anaesthetic. Its prolonged use can inhibit adrenal steroidogenesis and, following reports of reduced serum cortisol levels unresponsive to ACTH injection, the manufacturer suspended promotion of etomidate for sedation in intensive care in 1983. In 1985 regulatory action taken only in the United Kingdom further restricted use of the drug to induction of anaesthesia. Etomidate remains widely available and is currently registered for induction of anaesthesia in 34 countries and for maintenance of anaesthesia in 17 countries. It has never been registered for sedation. |
| Biological Functions | The pharmacological properties of etomidate (Amidate) are similar to those of the barbiturates, although its use may provide a greater margin of safety because of its limited effects on the cardiovascular and respiratory systems. Since it has a relatively short elimination halflife (t1/2β = 2.9 hours), in addition to its use as an induction agent, etomidate has been used as a supplement to maintain anesthesia in some critically ill patients. Etomidate is rapidly hydrolyzed in the liver. |
| General Description | Etomidate is a carboxylated imidazole intended for the inductionof general anesthesia. It is marketed as the morepotent R (+) isomer. It is believed to exert its anestheticeffect via positive modulation of the GABAA receptor. Itis not water soluble and is available in the United States as a2-mg/mL solution containing 35% v/v propylene glycol andin Europe as a soybean oil and medium-chain triglyceridesformulation. The propylene glycol has been associatedwith moderate-to-severe pain on injection and irritation ofthe vascular tissue. A high incidence of skeletal musclemovements were noted in about 32% of patients followingetomidate injection. Case reports of seizures are also foundin the literature. |
| Biological Activity | Etomidate is a general anesthetic with GABA modulatory and GABA-mimetic actions; selectively interacts with β 2- and β 3-subunit containing GABAA receptors. Short acting and potent hypnotic, with low toxicity.The possible neuroprotective effect of etomidate against streptozotocin-induced (STZ-induced) hyperglycaemia were investigated in the rat brain and spinal cord. Etomidate treatment demonstrated neuroprotective effect on the neuronal tissue against the diabetic oxidative damage. |
| Clinical Use | Etomidate should only beused for induction of anesthesia when the cardiac benefitsoutweigh the risks associated with adrenal insufficiency.Etomidate is quickly distributed throughout most organsin the body after intravenous administration and the tissueconcentrations equal and sometimes exceed the plasmaconcentrations. The lipid solubility of the drug allows it torapidly penetrate into the brain with peak concentrationsoccurring within 1 minute of administration. Etomidate israpidly metabolized in the plasma and liver via esterases.About 75% of the drug is eliminated in the urine as the inactiveester hydrolyzed carboxylic acid. |
| Side effects | Etomidate may cause pain on injection and may produce myoclonic muscle movements in approximately 40% of patients during its use as an induction anesthetic. In addition, etomidate can suppress the adrenocortical response to stress, an effect that may last up to 10 hours. |
| Veterinary Drugs and Treatments | Etomidate may be useful as an alternative to thiopental or propofol for anesthetic induction in small animals, particularly in patients with preexisting cardiac dysfunction, head trauma, or that are critically ill. |
| Drug interactions | Potentially hazardous interactions with other drugs Adrenergic neurone blockers: enhanced hypotensive effect. Antihypertensives: enhanced hypotensive effect. Antidepressants: avoid MAOIs for 2 weeks before surgery; increased risk of arrhythmias and hypotension with tricyclics. Antipsychotics: enhanced hypotensive effect. |
| Metabolism | Etomidate is hydrolyzed by hepatic esterases to the corresponding inactive carboxylic acid, with subsequent renal and biliary excretion terminating its action. Its apparent elimination half-life is approximately 5 to 6 hours, with a volume of distribution of 5 to 7 L/kg. Changes in hepatic blood flow or hepatic metabolism will have only moderate effects on etomidate disposition. Concerns regarding the ability of etomidate to precipitate myoclonic jerks and inhibit adrenal steroid synthesis have been reported. |
| Mode of action | The exact mechanism of action of etomidate is unknown. It is felt to induce sedation by interaction with GABA receptors. and likely enhances the activity of a-aminobutyric acid. However, it is not structurally related to benzodiazepines or to barbiturates. Of significantnote, etomidate exhibits no analgesic properties. |
We use more specialized packaging for the different products you order. We use aluminum foil bags to encrypt your package to prevent your product from being damaged in transit. If you are concerned about safety, we can send your package using "fake packaging" to replace the name of the product. Make sure you can receive your package safely. We use different packaging methods for liquids and powders. All in all you will be amazed by our shipping and packaging.
SHIPPING
We guarantee that your package will pass 100% through the Mexico US, UK, Australia, Netherlands, Canada, France, Germany, Spain, Belgium, Sweden, Poland, Russian, Ukraine, Kazakhstan, Czech Republic, Slovakia, Portugal.
We have freight forwarders in these countries, and our customs clearance company will clear your parcels without any customs issues, sometimes even 1000 kg. Door to door service. Make sure you receive 100% of the goods. Let you have a good experience of our strong freight capacity.
PAYMENT
Our company offers variety of products which can meet your multifarious demands. We adhere to the management principles of "quality first, customer first and credit-based" since the establishment of the company and always do our best to satisfy potential needs of our customers. Our company is sincerely willing to cooperate with enterprises from all over the world in order to realize a win-win situation since the trend of economic globalization has developed with. We can offer different quantities of custom synthetic chemicals on laboratory, factory and industrial scales. We can provide competitive prices for every customer and guarantee the quality of our products. We pay attention to the needs of each customer and build a good relationship with them. If you have any other questions for me. Please feel free to contact us. Our company provides a variety of products to meet your various needs. Since the establishment of the company, we adhere to the "quality first, customer first, credit oriented" business policy, always try our best to meet the potential needs of customers. With the development of economic globalization, our company is willing to cooperate sincerely with enterprises all over the world to achieve a win-win situation. We can supply different numbers of laboratory, factory and industrial scale custom synthetic chemicals. We can provide competitive prices for every customer and guarantee the quality of our products. We pay attention to the needs of each customer and build a good relationship with them. If you have any other questions for me. Please feel free to contact us. Our company offers variety of products which can meet your multifarious demands. We adhere to the management principles of "quality first, customer first and credit-based" since the establishment of the company and always do our best to satisfy potential needs of our customers. Our company is sincerely willing to cooperate with enterprises from all over the world in order to realize a win-win situation since the trend of economic globalization has developed with. We can offer different quantities of custom synthetic chemicals on laboratory, factory and industrial scales. We can provide competitive prices for every customer and guarantee the quality of our products. We pay attention to the needs of each customer and build a good relationship with them. If you have any other questions for me. Please feel free to contact us. Our company provides a variety of products to meet your various needs. Since the establishment of the company, we adhere to the "quality first, customer first, credit oriented" business policy, always try our best to meet the potential needs of customers. With the development of economic globalization, our company is willing to cooperate sincerely with enterprises all over the world to achieve a win-win situation. We can supply different numbers of laboratory, factory and industrial scale custom synthetic chemicals. We can provide competitive prices for every customer and guarantee the quality of our products. We pay attention to the needs of each customer and build a good relationship with them. If you have any other questions for me. Please feel free to contact us.
Professional factory and laboratory
1) Most products on stock, ship out within 1-3 days !
2) Products are tested by QC department strictly before shipping !
3) Make sure the part's safety with our strong shipping line !
4) Customs pass and satisfied rate ≥99% !
5) Responsible for all after-sale quality issues !
Q1. Can I have a sample order for your products?
A: Yes, we welcome sample order to test and check quality. Mixed samples are acceptable.
Q2. What about the lead time?
A:Sample needs 3-5 days, mass production time needs 1-2 weeks for order quantity more than
Q3. Do you have any MOQ limit for order?
A: Low MOQ, 10-100g for sample checking is available
Q4. How do you ship the goods and how long does it take to arrive?
A: We usually ship by DHL, UPS, FedEx or TNT. It usually takes 3-5 days to arrive. Airline and sea shipping also optional.
Q5. How to proceed an order for your products?
A: Firstly let us know your requirements or application.Secondly We quote according to your requirements or our suggestions.Thirdly customer confirms the samples and places deposit for normal order.Fourthly We arrange the production.
Q6. Is it OK to print my logo on package?
A: Yes. Please inform us before our production and confirm the design firstly based on our sample.
Q7: Are you trading company or manufacturer?
A: We are chemical factory in China. So we can provide wholesale price
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