J-147 is a broad spectrum neuroprotective phenyl hydrazide compound(EC50=60-115 nM) with significant neurotrophic properties related to the induction of brain-derived neurotrophic factor (BDNF).IC50 value: 60-115 nM in vitro assay [1]Target: J-147 has been shown to promotes HT22 and primary cell survival in a dose-dependent manner (EC50 value range of 0.06 - 0.115 μM) when applied to cell exposed to the mitochondrial neurotoxin, iodocetic acid (IAA), toxicity mediated by the excitatory amino acid glutamate, which causes HT22 cell death by an oxytosis mechanism. In the preclinical in vitro development assays, the EC50 value for J-147-induced cell survival is 25 nM. J-147 was metabolically unstable (highly metabolized) with only 12% of parent remaining after incubation with rat microsomes (phase 1 metabolism).

Introduction:

 J 147 is a novel neurotrophic drug for cognitive enhancement and Alzheimer's disease. J 147 is an exceptionally potent, orally active and broadly neuroprotective compound has the ability to enhance memory in normal animals as well as to prevent memory deficits in Alzheimer's disease (AD) transgenic mice. The neurotrophic and memory-enhancing activities of J147 are associated with an increase in brain derived neurotrophic factor (BDNF) levels and the expression of BDNF responsive proteins, the enhancement of LTP, the preservation of synaptic protein, the reduction of amyloid plaques.

Function:
 

Enhance mental intelligence; Boost memory and leaning capabilities;Improve brain power to solve problems and protect it from any chemical or physical injury;Enhance motivation level;Enhance the control of cortical/subcortical brain mechanism;Improve sensory perception. 

Chemical & Physical Properties

 

Store in a cool and ventilated warehouse. Keep away from fire and heat source. The storage temperature should not exceed 32 ºC, and the relative humidity should not exceed 80%. Keep away from light. The package shall be sealed and shall not come into contact with air. Provide corresponding varieties and quantities of fire-fighting equipment. The storage area shall be equipped with leakage emergency treatment equipment and appropriate receiving materials

Liquid:
Iron drum & plastic drum packaging
25kg per unit
100kg per unit
200kg per unit
1 ton per unit
Solid
Plastic bag & kraft paper bag & fiber drum
1kg per bag/drum
25kg per bag/drum

Packing:
1.Inner double plastic bags----25kg/Fiber drum (35*35*45cm, GW: 28kg,NW: 25kg);
2.Inner double plastic bags----5kg/Aluminum foil bag (GW: 6.5kg, NW: 5kg).
3.Inner double plastic bags----1kg/Aluminum foil bag (GW: 1.5kg,NW: 1kg).

Price negotiable based on order quantity
Payment Term West Union /Bitcoin/ Money Gram/TT
Delivery Time normally 5-10 days by express
Shipping way                 Express(EMS,DHL, TNT, FedEX, HKDHL, EUB, China Post, NL Post and other couriers), Door to Door
Shipping Period Within 5-12 days for most countries    

The FAQ
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3: What's your minimum quantity of an order

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4: When can you deliver the goods

If we have stock, we can usually arrange shipment 2 to 3 days after receiving payment. If not, the factory production time will prevail.

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step2: I will reply you with a quotation as soon as I receive you inquiry.

Step3: We will negotiate products, price, package, payment methods and so on.

Step4: You arrange the payment.

Step5: I will arrange the shipment after receiving you money.

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