CE, ISO9001 Approved MEK1/2 (S211) Polyclonal Antibody

Model NO.
BS3599
Host
Rabbit/Mouse
Reactivity
Human, Mouse, Rat
Certification
CE, ISO9001
Transport Package
Refrigerated Transport
Specification
100ug/1mg
Trademark
Bioworld
Origin
China
HS Code
300219000
Production Capacity
3000 Vials
Reference Price
$ 222.75 - 247.50
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Product Description

Catalog No. BS3599
Product Name MEK1/2 (S211) polyclonal antibody
Applications WB
Alternative Name Dual specificity mitogen-activated protein kinase kinase 1; MAP kinase kinase 1; MAPKK 1; MKK1; ERK activator kinase 1; MAPK/ERK kinase 1; MEK 1; MAP2K1; MEK-1; PRKMK1; Dual specificity mitogen-activated protein kinase kinase 2; MAP kinase kinase 2; MAPKK
Swiss-Prot Q02750    P36507   
Host Rabbit
Reactivity Human,Mouse,Rat
Application_all WB: 1:500~1:1000
Product Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Purification&Purity The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity MEK1/2 (S211) polyclonal antibody detects endogenous levels of MEK1/2 protein.
BiowMW ~ 43 kDa
Note For research use only, not for use in diagnostic procedure.
Immunogen Synthetic peptide, corresponding to amino acids 180-230 of Human MEK1.

  • Western blot (WB) analysis of MEK1/2 (S211) pAb at 1:500 dilution Lane1:CT26 whole cell lysate(40ug) Lane2:PC12 whole cell lysate(40ug) Lane3:Panc1 whole cell lysate(40ug) Lane4:A549 whole cell lysate(40ug) Lane5:Hela whole cell lysate(20ug)

Background

MEK1 (Mitogen activated protein kinase kinase 1) catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. MEK1 activates ERK1 and ERK2 MAP kinases. Mitogen activated protein kinase kinase 2 (MEK2 or MAPKK2) is a member of a family of tyrosine/threonine protein kinases that activate the ERK1 and 2 and MAPK enzymes by phosphorylating both residues within the threonine/glutamate/tyrosine (TEY) motif in the activation loop. MEK1 and 2 are also activated by dual phosphorylation, which occurs on serine 218 and 222, in the activation loop of the MEK. Threonine 292 of MEK1 is phosphorylated by ERK 2, which serves as a negative feedback loop by suppressing activation of MEK1. CE, ISO9001 Approved MEK1/2 (S211) Polyclonal Antibody



CE, ISO9001 Approved MEK1/2 (S211) Polyclonal Antibody CE, ISO9001 Approved MEK1/2 (S211) Polyclonal Antibody CE, ISO9001 Approved MEK1/2 (S211) Polyclonal Antibody CE, ISO9001 Approved MEK1/2 (S211) Polyclonal Antibody CE, ISO9001 Approved MEK1/2 (S211) Polyclonal Antibody CE, ISO9001 Approved MEK1/2 (S211) Polyclonal Antibody CE, ISO9001 Approved MEK1/2 (S211) Polyclonal Antibody

 

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