CE, ISO9001 Approved Mre11 (Q459) Polyclonal Antibody

Model NO.
BS2235
Host
Rabbit/Mouse
Reactivity
Human, Mouse, Rat
Certification
CE, ISO9001
Transport Package
Refrigerated Transport
Specification
100ug/1mg
Trademark
Bioworld
Origin
China
HS Code
300219000
Production Capacity
3000 Vials
Reference Price
$ 222.75 - 247.50
Contact Us

Product Description

Catalog No. BS2235
Product Name MRE11 (Q459) polyclonal antibody
Applications WB IHC IF
Alternative Name Double-strand break repair protein MRE11A; Meiotic recombination 11 homolog 1; MRE11 homolog 1; Meiotic recombination 11 homolog A; MRE11 homolog A; MRE11A; HNGS1; MRE11
Swiss-Prot P49959
Host Rabbit
Reactivity Human,Mouse,Rat
Application_all WB: 1:500~1:1000 IHC: 1:50~1:200 IF: 1:50~1:200
Product Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Purification&Purity The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity MRE11 (Q459) polyclonal antibody detects endogenous levels of MRE11 protein.
BiowMW ~ 80, 89 kDa
Note For research use only, not for use in diagnostic procedure.
Immunogen Synthetic peptide, corresponding to amino acids 400-500 of Human MRE11.

  • Western blot (WB) analysis of MRE11 (Q459) polyclonal antibody at 1:500 dilution Lane1:HepG2 whole cell lysate(40ug) Lane2:HEK293T whole cell lysate(40ug) Lane3:PC12 whole cell lysate(40ug) Lane4:AML-12 whole cell lysate(40ug)

  • Western blot (WB) analysis of MRE11 (Q459) pAb at 1:500 dilution Lane1:Jurkat whole cell lysate(40ug) Lane2:L02 whole cell lysate(40ug) Lane3:HEK293T whole cell lysate(40ug) Lane4:The heart tissue lysate of Mouse(40ug) Lane5:The heart tissue lysate of Rat

Background

DNA double-strand breaks are generated by ionizing radiation and endogenously produced radicals, and they often are repaired through the RAD52 homologous recombination pathway. The RAD52 family includes RAD51, RAD52, RAD54, RAD54B and MRE11 genes. Rad51 and Rad52 proteins perform the key steps in homologous recombination (HR), including the search for DNA homology and strand exchange, through similar mechanisms. Mre11 functions in both non-homologous end joining, and meiotic HR, and it is essential in mitosis for chromosome maintenance. Rad54 belongs to the SWI2/SNF2 subfamily of ATPases, which includes the DNA helicases involved in replication, recombination, and repair, as it contains seven amino acid sequence motifs that are largely conserved. Rad54 ATPase activity is dependent on double-stranded (ds) DNA, and the ATPase activity of Rad54 is not absolutely required for its DNA repair function, suggesting that these activities occur at distinct regions of the molecule. RAD54B is significantly homologous to the RAD54 recombination gene. Expression of RAD54B is highest in testis and spleen, which are active in both meiotic and mitotic recombination.. CE, ISO9001 Approved Mre11 (Q459) Polyclonal Antibody CE, ISO9001 Approved Mre11 (Q459) Polyclonal Antibody


CE, ISO9001 Approved Mre11 (Q459) Polyclonal Antibody CE, ISO9001 Approved Mre11 (Q459) Polyclonal Antibody CE, ISO9001 Approved Mre11 (Q459) Polyclonal Antibody CE, ISO9001 Approved Mre11 (Q459) Polyclonal Antibody CE, ISO9001 Approved Mre11 (Q459) Polyclonal Antibody CE, ISO9001 Approved Mre11 (Q459) Polyclonal Antibody CE, ISO9001 Approved Mre11 (Q459) Polyclonal Antibody

 

Biological Products

PNEUTEC.IT, 2023