Rxr Alpha (Phospho S260) Polyclonal Antibody

Model NO.
BS64567
Specification
100ug/1mg
Trademark
Bioworld
Origin
China
Production Capacity
3000 Vials
Reference Price
$ 222.75 - 247.50
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Product Description

Catalog No. BS64567
Product Name RXR alpha (Phospho-S260) polyclonal antibody
Applications WB
Alternative Name Retinoic acid receptor RXR-alpha; Nuclear receptor subfamily 2 group B member 1; Retinoid X receptor alpha; RXRA; NR2B1
Swiss-Prot P19793
Host Rabbit
Reactivity Human,Mouse,Rat
Application_all WB: 1:500~1:1000 IHC: 1:50~1:200
Product Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Purification&Purity The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity RXR alpha (Phospho-S260) polyclonal antibody detects endogenous levels of RXR alpha protein only when phosphorylated at Ser260.
BiowMW ~ 53 kDa
Note For research use only, not for use in diagnostic procedure.
Immunogen Synthetic phosphopeptide derived from human RXR alpha around the phosphorylation site of Serine 260.

  • Western blot (WB) analysis of RXR alpha (Phospho-S260) polyclonal antibody at 1:500 dilution LaneA:Hela whole cell lysate LaneB:The Brain tissue lysate of Mouse LaneC:The Brain tissue lysate of Rat

Background

The human retinoid X receptors (RXRs) are encoded by three distinct genes (RXRα, RXRβ, and RXRγ) and bind selectively and with high affinity to the vitamin A derivative, 9-cis-retinoic acid. RXRs are type-II nuclear hormone receptors that are largely localized to the nuclear compartment independent of ligand binding. Nuclear RXRs form heterodimers with nuclear hormone receptor subfamily 1 proteins, including thyroid hormone receptor, retinoic acid receptors, vitamin D receptor, peroxisome proliferator-activated receptors, liver X receptors, and farnesoid X receptor. Since RXRs heterodimerize with multiple nuclear hormone receptors, they play a central role in transcriptional control of numerous hormonal signaling pathways by binding to cis-acting response elements in the promoter/enhancer region of target genes. Retinoid X receptor α (RXRα) is the founding RXR family member and is predominantly expressed in liver, kidney, epidermis, intestine and a variety of tissues. Knockout of the murine rxrα gene results in embryonic lethality tentatively due to myocardial hypoplasia, which demonstrates the importance of RXRα to retinoid signaling in vivo. Biochemical evidence suggests that RXRα transcriptional activity is post-translationally regulated through the Ras-Raf-MAPK signaling cascade. MAPK-dependent phosphorylation of RXRα directly abrogates the ability of RXRα to associate with nuclear receptor coactivators. Rxr Alpha (Phospho S260) Polyclonal Antibody
Rxr Alpha (Phospho S260) Polyclonal Antibody Rxr Alpha (Phospho S260) Polyclonal Antibody Rxr Alpha (Phospho S260) Polyclonal Antibody

 

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