Basic Info.
Pro duct Name: | Semaglutide | |
Synonyms: |
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Molecular Formula: | C187H291N45O59 | |
Formula Weight: | 4113.57754 | |
Appearance: | Solid powder | |
Purity: | 99.9% | |
Storage: | Dry, dark, and at room temperature when unopened or 4-8 °C for the long term (months to years) when opened. | |
Solubility: | Soluble in DMSO | |
Shipping Condition: | Shipped under normal temperature. This product is stable enough during ordinary shipping and time spent in Customs. | |
CAS NO: | 10463-68-2 |
Function
Semaglutide
is the newest GLP-1R
agonist and was approved by the FDA as a once-weekly injection for the treatment of T2DM in late 2023. The peptide is chemically similar to liraglutide, with the inclusion of two structural modifications (Lau, Bloch, et al., 2015). The first is the replacement of Gly with the non-proteinogenic amino acid 2-aminoisobutyric acid (Aib) at position 2. The second is the attachment of octadecanoic diacid to the side chain of Lys-26 through a short polyethylene glycol (PEG) spacer and a γ-glutamic acid linker. The amino acid substitution renders the peptide more resistant to DPP-4 compared to liraglutide, and the presence of the 18-carbon fatty acid moiety results in a high binding affinity for serum albumin, which translates to a half-life of approximately 7 days in humans
Application
Weight loss
Anti-diabetes
Alzheimer's disease
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