Factory Supply Pure Vonoprazan Fumarate CAS 1260141-27-2 in Stock

Product Name: TAK-438
Synonyms: Vonaprazan;5-(2-Fluorophenyl)-N-methyl-1-(3-pyridinylsulfonyl)-1H-pyrrole-3-methanamine 2-butenedioate (Vonoprazan);1-[5-(2-fluorophenyl)-1-pyridin-3-ylsulfonylpyrrol-3-yl]-N-methylmethanamine;AK-438;Vonaprazan(TAK-438);vonoprazan(tak-438);Vonoprazan fumarate(TAK-438);vonoprazan(tak-438)1260141-27-2
CAS: 1260141-27-2
MF: C21H20FN3O6S
MW: 461.4634032
EINECS: 250-635-4

Melting point: >264°C (dec.)
Boiling point: 665.7±55.0 °C
Density: 1.3 g/mL at 37 °C
Storage temp.: Refrigerator
Appearance: White to Off-White Powder

Description:

Vonoprazan fumarate, discovered and developed by Takeda and Otsuka, was approved by the PMDA of Japan in December 2014, and is indicated for the treatment of gastric ulcer, duodenal ulcer and reflux esophagitis. Vonoprazan fumarate has a novel mechanism of action called potassium-competitive acid blockers, which competitively inhibit the binding of potassium ions to H+, K+-ATPase (also known as the proton pump) in the final step of gastric acid secretion in gastric parietal cells. Vonoprazan does not inhibit Na+, K+-ATPase activity even at concentrations 500 times higher than that of their IC50 values against gastric H+, K+-ATPase activity. Furthermore, the drug is unaffected by the gastric secretory state, unlike PPIs.

Uses:

Vonoprazan Fumarate is a novel potassium-competitive acid blocker for the treatment of acid-related diseases.

1. Rich experience: Our company is a professional production leading factory in China in pharmaceutical area of many years. 

2. Top quality: High quality guaranteed, once any problem is found, the package would be reshipped for you .

3. Security Shipping: Shipping by express (FedEx,UPS,DHL,EMS), by air. The most professional forwarder would be recommanded for you.

4. Fast delivery: We have stock, so we can delivery quickly once payment is received.

5. Quality service: We will give you warm after-sale service,if any question we will reply you within 24 hours.

6. Competitive prices: A discount would be given when you make a large order.

Our factory:


Our laboratory:


Our warehouse:

Hubei Yuanmeng Biological Technology Co., Ltd., which is located in Wuhan, China. We are specializing in the exportation of APIs, and plant extracts ect.

Our products has been exported to America, Australia, Brazil, the Europe, Middle East and other areas in the world. We have established close and stable cooperative relationships with over 200 domestic pharmaceutical and chemical enterprises. With high quality and favorable price, we′ re pleased to get your inquiry and we will reply you as soon as possible.

We will continue to forge ahead and strive hard for excellence, keep on exploring and progressing to develop more high-tech products with superior quality, to satisfy increasing demand of the clients, and create more value for our partners!


Contact us!

Hubei Yuanmeng Biological Technology Co., Ltd.
Room 3820, Building 2, Vanke Golden City, Hongshan District, Wuhan, Hubei, China
Fiona Wei / CEO