High Quality Pharmaceutical Raw Materials Fasudil Hydrochloride CAS 105628-07-7

Model NO.
Frazer-Fasudil Hydrochloride
Form
Powder
Test Method
HPLC
Assay
99% Fasudil Hydrochloride
Storage
Store Cool Dry Place
CAS No
105628-07-7
Shelf Life
2 Years
Appearance
White Powder
Grade
Pharmaceutical Intermediates
Transport Package
Foil Bag
Specification
99%
Trademark
Xi′an Frazer Biotech Co., Ltd.
Origin
China
Production Capacity
1000kg/Month
Reference Price
$ 90.00 - 450.00
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Product Description

High Quality Pharmaceutical Raw Materials  Fasudil   Hydrochloride  CAS 105628-07-7

High Quality Pharmaceutical Raw Materials Fasudil Hydrochloride CAS 105628-07-7
High Quality Pharmaceutical Raw Materials Fasudil Hydrochloride CAS 105628-07-7
Description: Fasudil, Monohydrochloride Salt is a cell-permeable, selective ROCK inhibitor which induces neuroprotection in vitro. Studies suggest that when acting as a ROCK inhibitor, Fasudil reduces neutrophil transendothelial migration by diminishing cytoskeletal rearrangement of endothelial cells. In addition, Fasudil significantly protects against MeHg-induced axonal degeneration and apoptotic cell death in cultured cortical neurons. Alternate studies show that Fasudil plays an important role in osteoblastic differentiation of stromal cells via increasing the mRNA expression of collagen-I, osteocalcin, and bone morphogenetic protein-2 (BMP-2). Furthermore, noggin, a BMP-2 antagonist can reverse the effects of Fasudil induced mRNA expression of collagen-I and osteocalcin. Upon inhibition of Rho-kinase, Fasudil significantly stimulates FGF-2-induced accumulation of vascular endothelial growth factor. Fasudil, Monohydrochloride Salt is an inhibitor of cGKI, MSK1, PKA, PRK2, Rock-2, CaMKII, Polycystin-1 and Rsk-1.
 

Function: Fasudil Hydrochloride is a new drug with a wide range of pharmacological effects, developed by Asahi Kasei Corporation (Japan.) It is a cardiovascular and cerebrovascular drug which improves symptoms of ischemic cerebrovascular disease such as cerebral vasospasm following subarachnoid hemorrhage. It has significant neuroprotective and therapeutic effects for ischemic cerebrovascular disease, and is suited for clinical use, particularly at the grassroots level to reduce mortality and improve quality of life.

Application: Fasudil Hydrochloride is an isoquinoline sulfonamide derivative which can relax separated cerebral blood vessels, inhibit the shrinkage of separated blood vessels caused by calcium influx, inhibit different mechanisms of brain blood vessel contraction from contractile agents, and inhibit intracellular calcium ion activity without reducing calcium ion concentration. Fasudil Hydrochloride is an RHO kinase inhibitor which dilates vessels, reduces tension of endothelial cells, and improves microcirculation of brain tissue without producing or exacerbating diversion of blood to the brain, by increasing activity of myosin light chain phosphatase. At the same time, it can protect nerves against apoptosis and promote their regeneration. Fasudil Hydrochloride promotes recovery of neural function and reduces clinical symptoms.

Specification:

Solution

 Easily solution in water, solution in m-ethanol

Appearance

White or off-white crystalline powder

Assay

99%min

Indentification

 

 UV

 Meets the requirements

 IR

 Consistent with reference specturm

 Chemical reaction

 Meets the requirements

 Color or solution

 not more intensely colored than refrence solution  Y1

 Clarify of solution

 not more palescent than refrence suspension solution 

Related substance

single impurity: 0.1%max

 

Total impurity:1.0%max

PH

4.5-6.0

Dimethylformamide

0.088%max

Aether

0.5%max

M-ethanol

0.3%max

D-ichloromethane

0.06%max

Moisture

2.5%max

Residue on ignition

0.1%max

Heavy metals

0.002%max

 

Pharmaceutical Intermediate

PNEUTEC.IT, 2023