Reliable Supplier of 99.9% High Purity Benzocaine Powder CAS: 94-09-7 No Customs Issues Safe Delivery

Model NO.
94-09-7
Refractive Index
1.5600 (Estimate)
Character
White Crystalline Powder
Density
1.1±0.1 g/cm3
Boiling Point
310.7±15.0 °c at 760 Mmhg
Einecs No
202-303-5
Molecular Weight
165.189
CAS
94-09-7
Molecular Formula
C9h11no2
Melting Point
88-90 °c
Transport Package
Packing Within 3 Working Days
Specification
25kg/Cardboard barrel
Trademark
Hoyan
Origin
Wuhan
HS Code
2922499990
Production Capacity
500000kg/Year
Reference Price
$ 90.00 - 180.00
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Product Description

Product Description

Benzocaine

 

 
Benzocaine structure
Reliable Supplier of 99.9% High Purity Benzocaine Powder CAS: 94-09-7 No Customs Issues Safe Delivery
Common Name Benzocaine
CAS Number 94-09-7 Molecular Weight 165.189
Density 1.1±0.1 g/cm3 Boiling Point 310.7±15.0 °C at 760 mmHg
Molecular Formula C 9 H 11 NO 2 Melting Point 88-90 °C
MSDS Chinese USA Flash Point 164.2±17.9 °C

 

   
       
       
       
       
       

Use of Benzocaine

 
Benzocaine shares a common receptor with all other local anesthetics (LAs) in the voltage-gated Na+ channel, with an IC50 of 0.8 mM tested with a potential of +30 mV.

Uses    Benzocaine is used as an anesthetic (Local and topical) that in products such as burn and sunburn remedies, hemorrhoidal creams, suppositories, creams for treatment of poison ivy, oral and gingival products, sore-throat sprays/lozenges, astringents, appetite suppressants, callus and wart remedies, athlete's-foot remedies, toothache- and denture-irritation products.

Description   Benzocaine (ethyl p-aminobenzoate) is used topically by itself or in combination with menthol or pheno in nonprescription dosage forms such as gels, creams, ointments, lotions, aerosols, and lozenges to relieve pain or irritation caused by such conditions as sunburn, insect bites, toothache, teething, cold sores or canker sores in or around the mouth, and fever blisters. Benzocaine is a lipophilic local anesthetic agent with a short duration of action.
Like most amino ester-type local anesthetics, it is easily hydrolyzed by plasma cholinesterase. Because of its low pKa, however, it is un-ionized under most physiological conditions and, therefore, can only bind to the lipid side of the local anesthetic receptor. It also can easily cross membranes into systemic circulation to cause systemic toxicities. Furthermore, being a PABA derivative, it has similar allergenic properties to procaine and is contraindicated with sulfonamide antibacterial agents.

Benzocaine (ethyl p-aminobenzoate) is used topically by itself or in combination with menthol or pheno in nonprescription dosage forms such as gels, creams, ointments, lotions, aerosols, and lozenges to relieve pain or irritation caused by such conditions as sunburn, insect bites, toothache, teething, cold sores or canker sores in or around the mouth, and fever blisters. Benzocaine is a lipophilic local anesthetic agent with a short duration of action.
Like most amino ester-type local anesthetics, it is easily hydrolyzed by plasma cholinesterase. Because of its low pKa, however, it is un-ionized under most physiological conditions and, therefore, can only bind to the lipid side of the local anesthetic receptor. It also can easily cross membranes into systemic circulation to cause systemic toxicities. Furthermore, being a PABA derivative, it has similar allergenic properties to procaine and is contraindicated with sulfonamide antibacterial agents.

Detailed Photos

Reliable Supplier of 99.9% High Purity Benzocaine Powder CAS: 94-09-7 No Customs Issues Safe Delivery
Reliable Supplier of 99.9% High Purity Benzocaine Powder CAS: 94-09-7 No Customs Issues Safe Delivery

Product Parameters


Benzocaine Biological Activity

Description Benzocaine shares a common receptor with all other local anesthetics (LAs) in the voltage-gated Na+ channel, with an IC50 of 0.8 mM tested with a potential of +30 mV.
Related Catalog
Signaling Pathways   >>   Membrane Transporter/Ion Channel   >>   Sodium Channel
Research Areas   >>   Neurological Disease
Target

IC50: 0.8 mM (Na+ channel)[1].

In Vitro Benzocaine blocks μ1 wild-type Na+ currents in a dose-dependent Manner. The Benzocaine concentration that inhibits 50% of Na+ currents (IC50) is estimated to be about 0.8 mM when a test potential of +30 mV is applied. The slope of the h∞ curve is also significantly reduced by benzocaine (from 6.6 to 9.9 mV). Mutation of μ1-N1584A also significantly increases the potency of Benzocaine. At 1 mM, Benzocaine blocks about 55% of wild-type Na+ current but about 95% of μ1-N1584A mutant current. Benzocaine also appears to bind more strongly to its LA receptor in the N1584A mutant than in the wild type[1]. The inhibition of Ca2+ uptake occurres at lower Benzocaine concentration (IC50=40.3±1.2mM) than that affecting the enzymatic activity[2].
In Vivo A common Benzocaine-containing anesthetic is topically applied to the following species: dogs, domestic shorthair cats, Long-Evans rats, Sprague-Dawley rats, ferrets, rhesus monkeys, cynomolgus monkeys, owl monkeys, New Zealand White rabbits, miniature pigs, ICR mice, C3H mice, and C57BL/10SnJ mice. All animals, except mice and rats, receive a 2-second spray to the mucous membranes of the nasopharynx for an estimated dose of 56 mg. A 2-second spray to rodents' oral mucous membranes delivers too great a volume of fluid for these animals. The study is repeated in dogs several months later to confirm low response. Response to Benzocaine spray is observed in most animals tested, with response peaking between 15 and 30 minutes after dosing[3].
References

[1].   Wang GK et al. A common local anesthetic receptor for benzocaine and etidocaine in voltage-gated mu1 Na+ channels. Pflugers Arch. 1998 Jan;435(2):293-302.

[2].   Di Croce D et al. Drug action of benzocaine on the sarcoplasmic reticulum Ca-ATPase from fast-twitch skeletal muscle. Naunyn Schmiedebergs Arch Pharmacol. 2015 Nov;388(11):1163-70.

[3].   Davis JA, et al. Benzocaine-induced methemoglobinemia attributed to topical application of the anesthetic in several laboratory animal species. Am J Vet Res. 1993 Aug;54(8):1322-6.

 

Chemical & Physical Properties

 
Density 1.1±0.1 g/cm3
Boiling Point 310.7±15.0 °C at 760 mmHg
Melting Point 88-90 °C
Molecular Formula C 9 H 11 NO 2
Molecular Weight 165.189
Flash Point 164.2±17.9 °C
Exact Mass 165.078979
PSA 52.32000
LogP 1.95
Vapour Pressure 0.0±0.7 mmHg at 25°C
Index of Refraction 1.555
Storage condition 0-6°C
Stability Stable. Combustible. Incompatible with strong oxidizing agents.

Certifications

Reliable Supplier of 99.9% High Purity Benzocaine Powder CAS: 94-09-7 No Customs Issues Safe Delivery

Packaging & Shipping

Storage:

1. Stored in a clean, cool and dry area; keep away from strong, direct light.

2. Shelf Life is 2 years when properly stored.

 

Packing:
1. Inner double plastic bags----25kg/Fiber drum (36*36*45cm, GW: 28kg, NW: 25kg);

2. Inner double plastic bags----5kg/Aluminum foil bag (GW: 6.5kg, NW: 5kg).

3. Inner double plastic bags----1kg/Aluminum foil bag (GW: 1.5kg, NW: 1kg).


P.S.: we accept packaging customization.

 

Delivery:

1. In stock products are normally shipping within 3 working days.

2. For rush delivery, please contact our sales team for particular arrangement

 

Shipping:

1. We ship goods via DHL, Fedex, UPS, TNT, China post, NL Post and other couriers, weight from 10g to 1000kg or even bulker.

2. Shipping details & shipping documents will be provided and sent by email.

3. We keep tracking the shippment until clients well received.

4. After years export shipping experience, with professional and experienced cooperated forwarders, we ensure that goods can be delivered in multiple ways safetly and efficiently.

Reliable Supplier of 99.9% High Purity Benzocaine Powder CAS: 94-09-7 No Customs Issues Safe Delivery Reliable Supplier of 99.9% High Purity Benzocaine Powder CAS: 94-09-7 No Customs Issues Safe Delivery Reliable Supplier of 99.9% High Purity Benzocaine Powder CAS: 94-09-7 No Customs Issues Safe Delivery

Hot sell products:

CHEMICAL NAME CAS No. STATE PRICE FREE SAMPLE
Benzocaine 94-09-7 IN STOCK Negotiable Available
Benzocaine HCI 23239-88-5 IN STOCK Negotiable Available
Lidocaine 137-58-6 IN STOCK Negotiable Available
Lidocaine hydrochloride 73-78-9 IN STOCK Negotiable Available
Tetracaine 94-24-6 IN STOCK Negotiable Available
Boric acid 11113-50-1 IN STOCK Negotiable Available
Levamisole (hydrochloride) 16595-80-5 IN STOCK Negotiable Available
Procaine (HCI) 51-05-8 IN STOCK Negotiable Available
Procaine 59-46-1 IN STOCK Negotiable Available

Payment term:

We accept various payment terms, the main methods are : T/T, L/C, Western Union, credit card, Bitcoin, USDT etc.
Reliable Supplier of 99.9% High Purity Benzocaine Powder CAS: 94-09-7 No Customs Issues Safe Delivery

Shipping term:
Reliable Supplier of 99.9% High Purity Benzocaine Powder CAS: 94-09-7 No Customs Issues Safe Delivery

 

Company Profile

Hongyan Pharmaceutical Technology (Wuhan) Co., Ltd.

 

Hongyan Pharmaceutical Technology (Wuhan) Co., Ltd. is a collection of scientific research. Produce. Processing. Export as one of the professional chemical production enterprises. Mainly engaged in pharmaceutical intermediates and various industrial chemicals. Based on good quality and very competitive price, we have many years of professional experience, our products are widely used in different countries around the world.

 

Our company adopts the strategic idea of customer first, quality first, reputation first, strengthens reform with advanced technology, improves the management system with the correct concept, and increases investment to improve equipment.

 

Our company works hand in hand with enterprises all over the world to achieve a win-win situation. In the business cooperation with customers, we always abide by the principle of equality and mutual benefit, and are deeply trusted and recognized by customers.

 

Our company adheres to the people-oriented business philosophy, strives for the needs of customers, produces high-quality products for the trust of customers, and provides preferential prices for customer satisfaction, our goal is to win the trust of customers with sincere service. Our company has a professional and experienced team, dedicated to providing every customer with efficient and high-quality service, establishing and improving a strict quality standard system to test products, based on national standards, and do our best to make customers satisfied with our quality.

 

Welcome to contact us to inquiry our products and services, and we will offer the most competitive prices and the best technical support.
Reliable Supplier of 99.9% High Purity Benzocaine Powder CAS: 94-09-7 No Customs Issues Safe Delivery

 

 

Our Advantages

WHY CHOOSE US
HoYan (Wuhan) is committed to helping clients reach their goals, to providing high quality products and efficient shipments.

Our strong sense of responsibility with client projects means that we are constantly striving to provide solutions, even for issues they aren't yet aware of.

This sense of responsibility also means we value and promote seamless interaction with clients, and ensure the best value is obtained from their research budget.

Our staff bring professional knowledge to clients, as well as efficient responding to the clients, have built long-term cooperated relationships.

FAQ

In this page, we will continue to update frequently asked questions and answers about the crystaline, Benzocaine powder, Lidocaine hcl powder, Procaine hcl crystal, fluffy Lidocaine, tetracaine chemical, crystaline tetramisole hydrochloride, and so on, Stay tuned....

  • Q: What's your advantage?

    A

    The series of natural extracted product are all self-developed, produced and tested. Mature production technology, strict quality management system and cost control system, ensure the product stability and competitive price.

  • Q: How to deal with quality complaints or the goods get loss?

    A

    Firstly, every batch of our product was tested by authorized independent third party, Analysis testing center, Shanghai branch, Chinese Academy of Science. We send goods to customers with test report and COA (or depends on customers' request).


    If it is our product quality issue or due to the force majeures, we will send you another shipment for free.
     

  • Q: Is there any discount?

    A: The price is negotiable. The more bigger quantity you order, the more competitive price you would get.
     

  • Q: How do you manage the delivery?

    A: Goods will be shipped within 24 hours (Chinese public holiday are excluded), usually shipping by DHL, Fedex, EMS, TNT, HKETK. We will ship with the special safe channel to ensure you getting goods on time.

  • Q: How to place an order?

    A: Inquiry + payment + shipping.

    Firstly, please send inquiry infor to us, including quantity, your target price, shipping method, packing request, destination etc.     We will reply you the quotation and lead time within 1-8 hours (different time zone).

    Second, pay for the order, we accept various payment terms, the main methods are: T/T, L/C, Western Union, credit card, BitCoin, USDT, Money Gram.

    After received the payment, we will ship out products immediately and share tracking number with you.

    And for sure, we keep tracking the shippment, and we provide after-service.
     

  • Q: Can I get some samples?

    A: Warmly welcome, we can provide samples for free, but the shipping cost will be covered by customers.

 

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