Galantamine hydrobromide is the hydrobromide salt of galantamine and is a cholinesterase inhibitor can be extracted from Amaryllidaceae Lycoris plant. The III-phase clinical trials in the United Kingdom in 1998 have showed that this drug had dual mechanism of action of both inhibiting acetylcholinesterase and regulating nicotinic receptors.
Therefore, galantamine can improve the cognitive abilities of Alzheimer's patients and has been already applied as the drug of the treatment of mild to severe Alzheimer's disease (AD) drugs and has entered into market in EC countries. "Chinese Pharmacopoeia" has included the both the raw material and injection of galantamine hydrobromide.
Specification:
Items | Specification |
Appearance | Brown to Brown yellow powder(Relate to Purity) |
Oder | Characteristic |
Taste | Characteristic |
Paiticle size | Pass 80 mesh |
Loss on drying | ≤5% |
Heavy metals | <10ppm |
As | <1ppm |
Pb | <3ppm |
Assay | Result |
Evodiamine | ≥10% |
Total Plate Count | <10000cfu/g or <1000cfu/g(Irradiation) |
Yeast & Mold | <300cfu/g or 100cfu/g(Irradiation) |
E.Coli | Negative |
Salmonella | Negative |
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