Leflunomide Details:
Chemical Name | 5-methyl-N-[4-(trifluoromethyl)phenyl]-4-isoxazole carboxamide |
Appearance | white or off white crystalline powder |
Quality standard | ≥99% |
Melting point | 163-168ºC |
CAS No. | 75706-12-6 |
MW | 270.2 |
MF | C12H9F3N2O2 |
Category | API |
Quality standard | USP |
Leflunomide Description:
Leflunomide (other name Arava) is an immunosuppressive disease-modifying antirheumatic drug (DMARD), used in active moderate-to-severe rheumatoid arthritis and psoriatic arthritis. It is a pyrimidine synthesis inhibitor that works by inhibiting dihydroorotate dehydrogenase.
Leflunomide Application:
1) Treating rheumatoid arthritis by reducing signs and symptoms, improving physical function, and preventing the development of structural damage to the joints.
2) Leflunomide is a pyrimidine synthesis inhibitor. It is thought to work by blocking certain enzymes responsible for abnormal tissue development or growth.
3) Leflunomide is often used to treat rheumatoid arthritis if other DMARDs, such as methotrexate, are not properly controlling symptoms.
4) Leflunomide can cause liver injury, so alcohol and certain other medications should be avoided while on Leflunomide. Blood work should be performed regularly by your rheumatologist to monitor liver function.
5) Leflunomide is often not prescribed to young women, because it can cause serious birth defects and can remain in the body long after the drug is discontinued.
Packing:
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