Product Description:
1. Levobupivacaine is a local anaesthetic drug belonging to the amino amide group. It is the S-enantiomer of bupivacaine. Levobupivacaine hydrochloride is commonly marketed by Abbott under the trade name Chirocaine.
2. Compared to bupivacaine, levobupivacaine is associated with less vasodilation and has a longer duration of action. It is approximately 13 percent less potent (by molarity) than racemic bupivacaine and has a longer motor block onset time. Levobupivacaine is indicated for local anaesthesia including infiltration, nerve block, ophthalmic, epidural and intrathecal anaesthesia in adults; and infiltration analgesia in children.
Specifications:
| Test Items | Specification | Test Results |
| Description | White or almost white crystalline powder | White crystalline powder |
| Melting Point | 191.0~193.0ºC | 192ºC |
| Loss of drying | ≤1.0% | 0.5% |
| Heavy Metal | ≤20ppm | 15ppm |
| TLC | Only one spot | Only one spot |
| Assay | ≥99.5% | 99.91% |
| Conclusion | It complies with the USP 32. | |
Applications:
1. Levobupivacaine (rINN) is a local anaesthetic drug belonging to the amino amide group. It is the S-enantiomer
of bupivacaine.
2. The hydrochloride salt of levobupivacaine, an amide derivative with anesthetic property. Levobupivacaine reversibly binds voltage-gated sodium channels to modulate ionic flux and prevent the initiation and
transmission of nerve impulses (stabilizing neuronal membrane), thereby resulting in analgesia and anesthesia.
In comparison with racemic bupivacaine, levobupivacaine is associated with less vasodilation and has a longer duration of action.
Chemical & Physical Properties
| Boiling Point | 423.4ºC at 760 mmHg |
|---|---|
| Melting Point | 254 °C (dec.)(lit.) |
| Molecular Formula | C 18 H 29 ClN 2 O |
| Molecular Weight | 324.889 |
| Flash Point | 209.9ºC |
| Exact Mass | 324.196838 |
| PSA | 23.55000 |
| LogP | 4.74080 |
| Vapour Pressure | 2.24E-07mmHg at 25°C |
Other Products
Hebei Best Biological Technology Co., Ltd. is a modern advanced enterprise specializing in production and exportation of APIs,Pharmaceutical intermediates, peptides, plant extracts etc. Our products are widely used in medicine, health care products, cosmetics, nutritional supplements and food additives areas. our factory covers an area of 95 acres, the proposed construction of the plant will be GMP standards, the factory environment clean and tidy, rational layout, with large and medium-sized production workshop and repocessed shop. It is equipped with advanced equipment quality inspection and research center. Those products of both quality and technical content have reached the domestic advanced level. Since its establishment, the company has attached great importance to the team training and technical reform. Our modern production equipment guarantees for a fast and effective production with a superior degree of accuracy throughout the whole production line,everything is done in-house ,processing, extraction, packaging and transportation of all links ,ensuring maximum quality and efficiency. We are constantly research and development new ingredients and innovative new products, have earned the respect & admiration from the worldwide customers. After years of continuous development,company has been accumulated rich experience in international trade and customer resources, established a stable customer base and perfect marketing service network. In addition, the company has established long-term technical cooperation with experts and professors from many universities and research institutes in the province. Excellent quality, reasonable price, rapid delivery and good service ensure us to satisfy all kinds of your demands. If you are interested in us, please contact me