CE، ISO 9001 معتمد من Grk 6 (N22) الجسم المضادّ متعدد الأضلاع

نموذج رقم.
BS1997
المضيف
أرنب/ماوس
إعادة النشاط
الإنسان والفأر والفأر
شهادة
CE، ISO9001
حزمة النقل
Refrigerated Transport
تخصيص
100ug/1mg
العلامة التجارية
Bioworld
الأصل
China
رمز النظام المنسق
300219000
القدرة الإنتاجية
3000 Vials
السعر المرجعي
$ 222.75 - 247.50
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وصف المنتجات

Catalog No. BS1997
Product Name GRK 6 (N22) polyclonal antibody
Applications WB IHC IF
Alternative Name G protein-coupled receptor kinase 6; G protein-coupled receptor kinase GRK6; GRK6; GPRK6;
Swiss-Prot P43250
Host Rabbit
Reactivity Human,Mouse,Rat
Application_all WB: 1:500~1:1000 IHC: 1:50~1:200 IF: 1:50~1:200
Product Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Purification&Purity The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity GRK 6 (N22) polyclonal antibody detects endogenous levels of GRK 6 protein.
BiowMW ~ 65 kDa
Note For research use only, not for use in diagnostic procedure.
Immunogen Synthetic peptide, corresponding to amino acids N-terminus of Human GRK 6.

  • Western blot (WB) analysis of GRK6 (N22) pAb at 1:500 dilution Lane1:H9C2 whole cell lysate(40ug) Lane2:CT26 whole cell lysate(40ug) Lane3:MCF-7 whole cell lysate(40ug) Lane4:HEK293T whole cell lysate(40ug) Lane5:HepG2 whole cell lysate(40ug)

Background

Heterotrimeric G protein-mediated signal transduction is a dynamically regulated process with the intensity of signal decreasing over time despite the continued presence of the agonist. This phenomenon, referred to as agonistmediated desensitization, involves phosphorylation of the receptor by two classes of enzymes. The first are the second messenger-regulated kinases such as c-AMP dependent protein kinase A and protein kinase C. The second are the G protein-coupled receptor kinases (GRKs). At least seven members of the GRK family have been identified. These include rhodopsin kinase, GRK 1; two forms of β-adrenergic receptor kinase, GRK 2 (βARK, βARK1) and GRK 3 (βARK2); IT-11 (GRK 4); GRK 5, GRK 6 and GRK 7. Phosphorylation of receptors by GRKs appears to be strictly dependent on the receptor being in its agonist-activated state. CE, ISO9001 Approved Grk 6 (N22) Polyclonal Antibody


CE, ISO9001 Approved Grk 6 (N22) Polyclonal Antibody CE, ISO9001 Approved Grk 6 (N22) Polyclonal Antibody CE, ISO9001 Approved Grk 6 (N22) Polyclonal Antibody CE, ISO9001 Approved Grk 6 (N22) Polyclonal Antibody CE, ISO9001 Approved Grk 6 (N22) Polyclonal Antibody CE, ISO9001 Approved Grk 6 (N22) Polyclonal Antibody CE, ISO9001 Approved Grk 6 (N22) Polyclonal Antibody

 

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