Bisibutiamine/Sulbutiamine CAS 3286 -46-2 Sulbutiamine

Sulbutiamine was developed in Japan as a more efficient version of vitamin B1. vitamin B1 (thiamine) is an essential nootropic vitamin and sulbutiamine mimics the effects of Thiamine at a more drastic level. Sulbutiamine is more efficient than thiamine at crossing the blood brain barrier and therefore much stronger in terms of effects. Sulbutiamine brings its own set of unique properties and can be used alone or stacked with other nootropics.

Density: 1.268g/cm3

Boiling point: 892.5ºC at 760mmHg

Flash point: 493.5ºC

Refractive index: 1.602

Storage conditions: The warehouse is ventilated and dry at low temperature


Method of Action

It is believed that sulbutiamine works similarly to thiamine however the effects are greatly enhanced. Thiamine is essential in the body and even more essential for cognitive function because it is used in the biosynthesis of acetylcholine and GABA. sulbutiamine is believed to have effects on the cholinergic, glutamatergic and dopamine systems which result in its nootropic benefits.

Benefits

Fatigue caused by an infection.  Early research suggests that taking sulbutiamine daily in addition to standard care for an infection over 15 days seems to help reduce weakness and Fatigue in people with an infection.  However, fatigue does not seem to improve when sulbutiamine is taken for longer periods of time.  Other research shows that taking sulbutiamine daily for 28 days does not improve fatigue in people with an infection.

Alzheimer's disease.  Early research suggests that taking sulbutriamine by mouth for 3 months improves attention in people with early stage Alzheimer's disease.  When it is combined with the anti-Alzheimer drug Donepezil(Aricept) for 3 months, it might also improve memory.

Depression.  Research suggests that taking sulbutriamine daily for 4 weeks improves one aspect of Depression called psycho-behavioral inhibition, but no other measurements of depression.

Diabetic nerve pain.  Research suggests that taking sulbutiamine (Arcalion) daily for 6 weeks improves how well nerves work in people with nerve damage caused by Diabetes.  However, it does not seem to improve symptoms of diabetic nerve pain in these patients.

Erectile dysfunction(ED).  Early evidence shows that taking sulbutiamine for 30 days improves Erectile dysfunction in 16 out of 20 men.

Fatigue related to multiple sclerosis(MS) .  Early evidence suggests that taking sulbutiamine for 6 months improves fatigue related to multiple sclerosis .

Function

1) Sulbutiamine is a synthetic derivative of thiamine (vitamin B1).

2) As a dimer of twomodified thiamine molecules, it is a lipophilic compound that crosses the blood-brain barrier more readily than thiamine and increases the levels of thiamine and thiamine phosphate esters in the brain. 
3) Sulbutiamine was discovered in Japan in an effort to develop more useful thiamine derivatives since it was hoped that increasing the lipophilicity of thiamine would result in better pharmacokinetic properties.
Sulbutiamine (isobutyryl thiamine disulfide) is a lipophilic derivative of thiamine used for the treatment of asthenia and other related pathological conditions. Sulbutiamine is available over-the-cou nter in several countries as a component of nutritional supplements.

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