Products DescriptionHigh Purity Fast Delivery Sugammadex Sodium CAS 343306-79-6
Product Name: Sugammadex sodium
Synonyms: ORG-25969/SugaMMadex;Sugammadex Na;ORG;Sugammadex IMP;Sugammadex soidum 343306-79-6;Sugammadex sodium iMpurity;6A,6B,6C,6D,6E,6F,6G,6H-octakis-S-(2-Carboxyethyl)-6A,6B,6C,6D,6E,6F,6G,6H-octathio-γ-cyclodextrin Sodium Salt;Sugammadex Sodium salt
CAS: 343306-79-6
MF: C72H104Na8O48S8
MW: 2177.97
EINECS: 687-766-5Items | Specifications |
CAS | 343306-79-6 |
Density | 1.275g/cm3 |
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Molecular Formula | C72H104Na8O48S8 |
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Molecular Weight | 2178.01000 |
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Exact Mass | 2176.26000 |
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PSA | 994.8000 |
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General Description:
To facilitate tracheal intubation, mechanical ventilation, and surgical access, NMB agents are frequently used as non-anesthetic adjuncts in surgical procedures. Sugammadex is able to function as a pharmacologic sink of rocuronium and vecuronium, another non-depolarizing neuromuscular blocker, without the cardiovascular adverse effects experienced with reversal agents that directly interact with the cholinergic system. The γ-cyclodextrin has been designed to enhance binding of the guest by incorporating acidic side chains to promote an electrostatic interaction with the positive nitrogen of the blocker. Starting with γ-cyclodextrin, these side chains are readily installed by first halogenating with iodine or bromi ne to provide a handle for nucleophilic displacement with either 3-mercaptopropionic acid in the presence of sodium hyd ride or with 3-mercaptopropionic acid methyl ester and cesium carbonate. The latter requires hydrolysis with sodium hydro xide to generate sugammadex sodium.
Uses: Sugammadex Sodium is the first in a class of drugs called selective relaxant binding agents that offers improved termination of the paralytic effects of neuromuscular blocking agents and may have many potential peri-operative benefits.
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