Factory Price Pharmaceutical Grade Capecitabine Powder CAS 154361-50-9
Specification of Analysis
Product Name
|
Capecitabine
|
Appearance
|
White powder
|
Molecular formula
|
C15h22fn3o6
|
Molecular Weight
|
359.35
|
CAS
|
154361-50-9
|
Melting Point
|
110-121°C
|
What is
Capecitabine
?
Capecitabine is rapidly absorbed by the intestinal mucosa after oral administration, and then converted into an inactive
intermediate 5'-deoxy-5' fluorocytidine in the liver by carboxyl esterase, followed by cytidine removal from liver and
tumor tissues. The action of the aminoase is converted to 5'-deoxy-5' fluorouridine and finally catalyzed by thymidine
phosphorylase to fluorouracil (5-FU) in tumor tissues.
Clinical studies have shown that the concentration of 5-FU in tumor tissue after oral administration is significantly
higher than that of blood and muscle. The efficacy of tumors in a variety of animals was significantly higher than 5-FU.
Function
1.Colorectal Cancer (either as neoadjuvant therapy with radiation, adjuvant therapy or for metastatic cases)
2.Breast cancer (Metastatic or as monotherapy/combotherapy, this is licensed as a second-line treatment in Uk)
3.Gastric Cancer (off-label in the US, this is licensed indication in UK)
4.Oesophageal Cancer (off-label in US)
Application
Anticancer drugs are mainly used for non-small cell lung cancer, pancreatic cancer, bladder cancer, breast cancer and other solid tumors.