API Nootropic Madicine Materials Alpha GPC/ Citicoline/J-147/ Oxiracetam CAS 1146963-51-0/1346013-80-6/62613-82-5/28319-77-9/987-78-0/1270138-40-3/22503-72-6

Description:
NSI-189 is a nootropic and neurogenic research chemical derived from nicotinamide and pyrazine.IC50 value:Target: in vitro: NSI-189 has been shown to stimulate neurogenesis of human hippocampus-derived neural stem cells in vitro and in vivo. The hippocampus is responsible for the consolidation of information from short-term memory to long-term memory, along with spatial navigation [1] [2].in vivo: NSI-189 has been shown to increase the hippocampal volume of healthy adult mice by 20%
 

NSI-189
Other Names:NSI-189 Phosphate, (4-benzylpiperazin-1-yl)-[2-(3-methylbutylamino)pyridin-3-yl]methnone
Molecular Formula:C22H30N4O
Formula Weight:366.4998
CAS No.:1270138-40-3
Appearance:off-white powder
Purity:99%

 
Background:

NSI-189 is a benzylphiperizine-aminiopyridine, nootropic and neurogenic research chemical created by Neuralstem, Inc. that was derived from pyrazine and nicotinamide. Studies have shown that it stimulates neurogenesis of human hippocampus-derived neural stem cells in vivo and vitro . In healthy adult mice, NSI-189 has been shown to increase the hippocampal volume by 20% and reverse behavioral symptoms in mouse depression models, meaning at the source it could address depression . The hippocampus is responsible for spatial navigation, along with the consolidation of information from short-term memory to long-term memory.

The chemical entity stimulates new neuron growth in the hippocampus, which is an area of the brain that is believed to be contributory in conditions such as post-traumatic stress disorder (PTSD), Alzheimer's disease, and major depressive disorder (MDD).

Although it has been demonstrated in rats and chimps, the suggestion that having too small of a hippocampus causes depression and other diseases in humans is still technically just a theory. NSI-189 increases hippocampal volume in adult mice by 20%, a region of the brain that is one of the first to suffer damage resulting in memory loss, disorientation, encephalitis, and hypoxia from disease's such as Alzheimer's .

 Benefits:

Tests have shown that NSI-189 significantly improved behavioral responses that are associated with depression . In humans it may counter hippocampal atrophy which is seen in disorders such as MDD, reversing their symptoms. A phase 1B randomized, double-blind, placebo-controlled, multiple-dose escalation study conducted over a 28 day period showed behavioral efficacy in 24 patients who were orally administered NSI-189 . The efficacy measurements showed a clinically meaningful reduction in cognitive and depressive symptoms across all measures, and appeared to persist over time during follow up for the efficacy assessments which included the Clinical Global Impression - Improvement (CGI-I), Montgomery-Aserb Depression Rating Scale (MADRS), Cognitive and Physical Functioning Questionnaire (CPFQ, and the Symptoms of Depression Questionnaire (SDQ) .

 COA :

Chemical & Physical Properties

Density	1.1±0.1 g/cm3
Boiling Point	485.6±45.0 °C at 760 mmHg
Melting Point	216-217ºC (decomposition)
Molecular Formula	C 19 H 22 Cl 2 N 2 O 2
Molecular Weight	381.30
Flash Point	247.5±28.7 °C
PSA	43.71000
LogP	2.64
Appearance of Characters	powder,faint yellow to dark yellow
Vapour Pressure	0.0±1.2 mmHg at 25°C
Index of Refraction	1.580
Storage condition	2-8°C
Water Solubility	H2O: >5mg/mL

Store in a cool and ventilated warehouse. Keep away from fire and heat source. The storage temperature should not exceed 32 ºC, and the relative humidity should not exceed 80%. Keep away from light. The package shall be sealed and shall not come into contact with air. Provide corresponding varieties and quantities of fire-fighting equipment. The storage area shall be equipped with leakage emergency treatment equipment and appropriate receiving materials

Liquid:
Iron drum & plastic drum packaging
25kg per unit
100kg per unit
200kg per unit
1 ton per unit
Solid
Plastic bag & kraft paper bag & fiber drum
1kg per bag/drum
25kg per bag/drum

Packing:
1.Inner double plastic bags----25kg/Fiber drum (35*35*45cm, GW: 28kg,NW: 25kg);
2.Inner double plastic bags----5kg/Aluminum foil bag (GW: 6.5kg, NW: 5kg).
3.Inner double plastic bags----1kg/Aluminum foil bag (GW: 1.5kg,NW: 1kg).

Price negotiable based on order quantity
Payment Term West Union /Bitcoin/ Money Gram/TT
Delivery Time normally 5-10 days by express
Shipping way                 Express(EMS,DHL, TNT, FedEX, HKDHL, EUB, China Post, NL Post and other couriers), Door to Door
Shipping Period Within 5-12 days for most countries    

The FAQ
1: How do I start ordering or paying

You can either send your purchase order or just send a simple confirmation via email or trade manager and we will send you a proforma invoice with our bank details for your confirmation and then you can pay accordingly.

2: How to pay

We can accept L/C, T/T, Western Union, Money Gram, Paypal, etc

3: What's your minimum quantity of an order

For high value products, our minimum order quantity starts from 1G and generally starts from 10GS. For other low price items, our minimum orders start at 100g and 1kg.

4: When can you deliver the goods

If we have stock, we can usually arrange shipment 2 to 3 days after receiving payment. If not, the factory production time will prevail.

How to proceed an order?

Step 1: When you intended to buy something, pls send me an inquiry by email, wicker or whatsapp.

step2: I will reply you with a quotation as soon as I receive you inquiry.

Step3: We will negotiate products, price, package, payment methods and so on.

Step4: You arrange the payment.

Step5: I will arrange the shipment after receiving you money.

Step6: The tracking number and the picture of the parcel will be sent to you.

Step7: Trace the tracking number on website until you receive