CAS 54-47-7 High Quality Pyridoxal Phosphate

Model NO.
Pyridoxal Phosphate
Einecs No.
200-208-3
Storage
Cool Dry Place
Shelf Life
24 Months
Mf
C8h10no6p
MW
247.14
CAS
54-47-7
Transport Package
1kg/Bag, 25kg/Drum
Specification
Pyridoxal Phosphate
Trademark
HNB
Origin
China
Production Capacity
5000kg/Month
Reference Price
$ 162.00 - 180.00
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Product Description

CAS 54-47-7 High Quality Pyridoxal Phosphate
Product Name Pyridoxal Phosphate
CAS 54-47-7
EINECS No 200-208-3
Molecular Formular C8H10NO6P
Molecular Weight 247.14
Appearance White to light yellow powder

Pyridoxal phosphate (PLP, pyridoxal 5'-phosphate, P5P), the active form of vitamin B6, is a coenzyme in a variety of enzymatic reactions. The Enzyme commission has catalogued more than 140 PLP-dependent activities, corresponding to ~4% of all classified activities. The versatility of PLP arises from its ability to covalently bind the substrate, and then to act as an electrophilic catalyst, thereby stabilizing different types of carbanionic reaction intermediates.

Funtion:
PLP acts as a coenzyme in all transamination reactions, and in certain decarboxylation, deamination, and racemization reactions of amino acids.The aldehyde group of PLP forms a Schiff-base linkage (internal aldimine) with the ε-amino group of a specific lysine group of the aminotransferase enzyme. The α-amino group of the amino acid substrate displaces the ε-amino group of the active-site lysine residue in a process known as transaldimination. The resulting external aldimine can lose a proton, carbon dioxide, or an amino acid sidechain to become a quinoid intermediate, which in turn can act as a nucleophile in several reaction pathways.
In transamination, after deprotonation the quinoid intermediate accepts a proton at a different position to become a ketimine. The resulting ketimine is hydrolysed so that the amino group remains on the complex.
 
Application:
In addition, PLP is used by aminotransferases (or transaminases) that act upon unusual sugars such as perosamine and desosamine. In these reactions, the PLP reacts with glutamate, which transfers its alpha-amino group to PLP to make pyridoxamine phosphate (PMP). PMP then transfers its nitrogen to the sugar, making an amino sugar.
PLP is also involved in various beta-elimination reactions such as the reactions carried out by serine dehydratase and GDP-4-keto-6-deoxymannose-3-dehydratase (ColD).
It is also active in the condensation reaction in heme synthesis.
PLP plays a role in the conversion of levodopa into , facilitates the conversion of the excitatory neurotransmitter glutamate to the inhibitory neurotransmitter GABA, and allows SAM to be decarboxylated to form propylamine, which is a precursor to polyamines. 

CAS 54-47-7 High Quality Pyridoxal Phosphate
CAS 54-47-7 High Quality Pyridoxal Phosphate CAS 54-47-7 High Quality Pyridoxal Phosphate CAS 54-47-7 High Quality Pyridoxal Phosphate CAS 54-47-7 High Quality Pyridoxal Phosphate CAS 54-47-7 High Quality Pyridoxal Phosphate CAS 54-47-7 High Quality Pyridoxal Phosphate

 

Pharmaceutical Intermediate

PNEUTEC.IT, 2023