CE, ISO9001 Approved Matriptase (K21) Polyclonal Antibody

Model NO.
BS2574
Reactivity
Human, Mouse, Rat
Application_All
Wb: 1:500~1:1000 Ihc/If: 1:50~1:200 IP: 1:10~1:100
Host
Rabbit
Transport Package
Refrigerated Transport
Specification
100ug/1mg
Trademark
Bioworld
Origin
China
HS Code
300219000
Production Capacity
3000 Vials
Reference Price
$ 222.75 - 247.50
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Product Description

Catalog No. BS2574
Product Name Matriptase (K21) polyclonal antibody
Applications WB IHC IF IP
Alternative Name Suppressor of tumorigenicity 14 protein; Matriptase; Membrane-type serine protease 1; MT-SP1; Prostamin; Serine protease 14; Serine protease TADG-15; Tumor-associated differentially-expressed gene 15 protein; ST14; PRSS14; SNC19; TADG15
Swiss-Prot Q9Y5Y6
Host Rabbit
Reactivity Human,Mouse,Rat
Application_all WB: 1:500~1:1000 IHC/IF: 1:50~1:200 IP: 1:10~1:100
Product Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Purification&Purity The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity Matriptase (K21) polyclonal antibody detects endogenous levels of Matriptase protein.
BiowMW ~ 90 kDa
Note For research use only, not for use in diagnostic procedure.
Immunogen Synthetic peptide, corresponding to the N-terminual of Human Matriptase.

  • Western blot (WB) analysis of Matriptase (K21) pAb at 1:500 dilution Lane1:C6 whole cell lysate(40ug) Lane2:CT26 whole cell lysate(40ug) Lane3:HCT116 whole cell lysate(40ug) Lane4:PC3 whole cell lysate(40ug)

  • Immunoprecipitation of HEK293T cell lysate using Matriptase (K21) pAb (Sepharose Bead Conjugate) #BD0048(lane 2 and lane 3) .Lane 1 is 30% input. The western blot was probed using Matriptase (K21) #BS2574."↑"(supernatant); "↓(deposition)

Background

Matriptase (also known as MT-SP1, ST14, prostamin and epithin in mouse) is a tumor-associated type II transmembrane serine protease that is highly expressed in many human cancer-derived cell lines and is implicated in extracellular matrix re-modeling, tumor growth, and metastasis. Matriptase performs pleiotropic functions in the development of the epidermis, hair follicles, and cellular immune system. Sphingosine 1-phosphate (S1P, SPP), present in serum-derived lipoproteins, activates matriptase while matriptase activates both urokinase-type plasminogen activator and hepatocyte growth factor (HGF). Hepatocyte growth factor activator inhibitor type 1 (HAI-1) is a Kunitz-type serine protease inhibitor identified as a strong inhibitor of matriptase and HGF. CE, ISO9001 Approved Matriptase (K21) Polyclonal Antibody CE, ISO9001 Approved Matriptase (K21) Polyclonal Antibody
CE, ISO9001 Approved Matriptase (K21) Polyclonal Antibody CE, ISO9001 Approved Matriptase (K21) Polyclonal Antibody

 

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