Free Sample Pharmaceuticl Intermediate BMK Pmk Powder Diltiazem Hydrochloride CAS 33286 -22-5 in Stock
Model NO.
33286-22-5
Sample
Avaiable
Transport Package
Various Packaging/According to Your Request
Specification
99%
Trademark
huayiyiyao
Origin
China
Production Capacity
5000kg/Year
Reference Price
$ 54.00 - 72.00
Description
Product Description
Product Description
diltiazem hydrochloride Biological Activity
| Description | Diltiazem hydrochloride is a Ca2+ influx inhibitor (slow channel blocker or calcium antagonist). | ||||||||||||
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| Related Catalog |
Signaling Pathways
>>
Membrane Transporter/Ion Channel
>>
Calcium Channel
Research Areas
>>
Cardiovascular Disease
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| In Vitro | Benzothiazepine Ca2+ antagonist diltiazem hydrochloride interacts with transmembrane segments IIIS6 and IVS6 in the α1 subunit of L-type Ca2+ channels[1]. Diltiazem causes a dose-dependent inhibiton of contractions as well as Ca2+ influx stimulated by alpha adrenoceptor activation and high-K+ depolarization. Diltiazem is roughly equally potent in inhibiting contractions induced by high-K+ and a low concentration of norepinephrine (NE)[2]. Diltiazem also inhibits the Na-dependent Ca-efflux from heart mitochondria. Both the (+)-optical isomers of the cis- and trans-forms of diltiazem inhibit Na-Ca exchange activity with comparable potency (IC50 of 10-20 μM)[3]. | ||||||||||||
| In Vivo | Diltiazem produces a noncompetitive inhibition of Ca2+-induced contractions of depolarized rabbit aorta. Furthermore, there is a lack of parallelism between the smooth muscle effects of removal of [Ca2+]ex and of addition of diltiazem[2]. Diltiazem improves the cardiac microcirculation and function in an experimental model of hyperthyroidism in rats. The treatment of hyperthyroid rats with losartan diltiazem (4.7±0.7%; P < 0.001) significantly reduces the percentage of fibrosis areas in the left ventricle [4]. In conscious spontaneously hypertensive rats (SHR), diltiazem dose-dependently decreases the blood pressure and increases the heart rate after intravenous administration (0.03--1 mg/kg). Oral administration of diltiazem (100 mg/kg) also reduces the blood pressure of SHR[5]. | ||||||||||||
| Solvent |
In Vitro:
H 2 O : 33.33 mg/mL (73.91 mM; Need ultrasonic) |
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| Solubility |
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| Storage |
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| Shipping | Room temperature in continental US; may vary elsewhere | ||||||||||||
| SMILES | CN(C)CCN1C2=CC=CC=C2S[@H](C3=CC=C(OC)C=C3)[@H](OC(C)=O)C1=O.Cl | ||||||||||||
| References |
[1]. Kraus RL, et al. Molecular mechanism of diltiazem interaction with L-type Ca2+ channels. J Biol Chem. 1998 Oct 16;273(42):27205-12. [2]. van Breemen C, et al. The mechanism of inhibitory action of diltiazem on vascular smooth muscle contractility. J Pharmacol Exp Ther. 1981 Aug;218(2):459-63. [3]. Chiesi M, et al. Stereospecific action of diltiazem on the mitochondrial Na-Ca exchange system and on sarcolemmal Ca-channels. Biochem Pharmacol. 1987 Sep 1;36(17):2735-40. [4]. Freitas F, et al. Cardiac microvascular rarefaction in hyperthyroid rats is reversed by losartan, diltiazem. Fundam Clin Pharmacol. 2015 Feb;29(1):31-40. [5]. Sato M, et al. Hypotensive effects of diltiazem hydrochloride in the normotensive, spontaneously hypertensive and renal hypertensive rats (author's transl). Nihon Yakurigaku Zasshi. 1979 Mar;75(2):99-106. |
Chemical & Physical Properties
| Density | 1.26g/cm3 |
|---|---|
| Boiling Point | 594.4ºC at 760mmHg |
| Melting Point | 212-214 °C |
| Molecular Formula | C 22 H 27 ClN 2 O 4 S |
| Molecular Weight | 450.979 |
| Flash Point | 313.3ºC |
| Exact Mass | 450.138000 |
| PSA | 84.38000 |
| LogP | 4.23550 |
| Index of Refraction | 118 ° (C=1, H2O) |
| Storage condition | 2-8°C |
| Water Solubility | soluble |
Huayi Pharmaceutical Nanjing Co., Ltd. is a high-tech enterprise mainly engaged in the research and development and sales of high-quality drugs, agricultural chemicals, pharmaceutical intermediates and other related products. In terms of analysis and testing equipment, our company has an advanced and complete supporting system, forming an advanced chemical synthesis can quickly meet the personalized and serialized requirements for industrial production.
Our team by senior industry background and rich market experience of doctor, master and other professionals, committed to the relevant enterprises and institutions and research institutions at home and abroad to provide high-quality chemical products, can not only meet such customers special requirements for products, packaging and purity, and can satisfy the test in manufacturing from the mass production at various stages of comprehensive requirements.
Our team by senior industry background and rich market experience of doctor, master and other professionals, committed to the relevant enterprises and institutions and research institutions at home and abroad to provide high-quality chemical products, can not only meet such customers special requirements for products, packaging and purity, and can satisfy the test in manufacturing from the mass production at various stages of comprehensive requirements.
Our adhering to the "scientific development, green development, innovation and development" concept of development, customer success as own duty, makes every effort to to offer the best products, quality service to our customers.
Our company offers variety of products which can meet your multifarious demands. We adhere to the management principles of "quality first, customer first and credit-based" since the establishment of the company and always do our best to satisfy potential needs of our customers. Our company is sincerely willing to cooperate with enterprises from all over the world in order to realize a win-win situation since the trend of economic globalization has developed with anirresistible force.
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