Megestrol; 17-Hydroxy-6-Methylpregna-4, 6-Diene-3, 20-Dione; 20-Dione, 17-Hydroxy-6-Methyl- Pregna -6-Diene-3; CAS3562-63-8

Colour
White
Shelf Life
2-3 Years
Lead Time
5-7 Working Days
Transport
Air/Express/Sea
MOQ
10g
Site Audit
Available
Certificates
ISO9001/SGS
Stocks
in Stock
Package
1kg/5kg/10kg/25kg
Purity
99%
Samples
Available
Transport Package
Drum/Bottle/Bags
Trademark
Yunbang
Origin
China
Reference Price
Please contact us for quote
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Product Description

Megestrol;17-hydroxy-6-methylpregna-4,6-diene-3,20-dione;20-dione,17-hydroxy-6-methyl-pregna-6-diene-3;CAS3562-63-8

Megestrol; 17-Hydroxy-6-Methylpregna-4, 6-Diene-3, 20-Dione; 20-Dione, 17-Hydroxy-6-Methyl-Pregna-6-Diene-3; CAS3562-63-8  
Megestrol Chemical Properties
Melting point  207-208 °C(Solv: ethyl ethe r ; aceton e )
Boiling point  500.4±50.0 °C(Predicted)
density  1.15±0.1 g/cm3(Predicted)
pka 13.00±0.70(Predicted)
CAS DataBase Reference 3562-63-8(CAS DataBase Reference)
 
Safety Information
Hazardous Substances Data 3562-63-8(Hazardous Substances Data)
 
MSDS Information
 
 
Megestrol Usage And Synthesis
Chemical Properties White Solid
Uses Megestrol is an orally active progestogen. Megestrol is used in combinations as oral contraceptive and as antineoplastic agent.
Definition ChEBI: A 3-oxo Delta4-steroid that is pregna-4,6-diene-3,20-dione substituted by a hydroxy group at position 17.
Indications As a representitive of the compounds of the class of progestins, this drug is used for various forms of cancer, in particular cancer of the breast, kidneys, and others.
Brand name Megace (Bristol-Myers Squibb); Megace (Par);Citestrol;Co-ervonum;Combiquens;Femagest;Kombiquens;Megecat;Megeron;Megestat;Menoquens;Neo-delpregnin;Niaestine;Niagestine;Novaquin;Novokvens;Novolina;Novoquens;Oracolnal;Ovaban;Ovarid;Pallace;Serial 28;Volidan;Volplan.
World Health Organization (WHO) Megestrol acetate, a synthetic progestogen, was introduced in the early 1960s as a component in oral contraceptive preparations. In 1967, as a result of new regulations required by the United States Food and Drug Administration, megestrol acetate was submitted to long-term toxicity studies and by the early 1970s it was shown to be associated with an increased incidence of mammary tumours in beagle bitches which led to its withdrawal by several regulatory authorities. Subsequently the validity of the beagle bitch model as a predictor of carcinogenicity of steroid contraceptives has been contested by many national regulatory authorities and megestrol remains available in some countries for contraceptive purposes. In other countries its use is restricted to anticancer treatment. (Reference: (WHODI) WHO Drug Information, 1-3, 5-7, 1984)
Chemical Synthesis Megestrol, 17α-hydroxy-6α-methylpregna-4,6-dien-3,20-dione acetate (28.3.9), is a product of dehydrogenation medroxyprogesterone (28.3.7) with chloranil (tetrachloro-p-benzoquinone) in the presence of p-toluenesulfonic acid, which results in the formation of an additional double bond at position C6-C7, and subsequent acetylation of the product (28.3.8) leads to the desired megestrol (28.3.9) by acetic anhydrid e in the presence of p-toluenesulfonic acid.
 
Megestrol; 17-Hydroxy-6-Methylpregna-4, 6-Diene-3, 20-Dione; 20-Dione, 17-Hydroxy-6-Methyl-Pregna-6-Diene-3; CAS3562-63-8
Megestrol; 17-Hydroxy-6-Methylpregna-4, 6-Diene-3, 20-Dione; 20-Dione, 17-Hydroxy-6-Methyl-Pregna-6-Diene-3; CAS3562-63-8 Megestrol; 17-Hydroxy-6-Methylpregna-4, 6-Diene-3, 20-Dione; 20-Dione, 17-Hydroxy-6-Methyl-Pregna-6-Diene-3; CAS3562-63-8 Megestrol; 17-Hydroxy-6-Methylpregna-4, 6-Diene-3, 20-Dione; 20-Dione, 17-Hydroxy-6-Methyl-Pregna-6-Diene-3; CAS3562-63-8
Company Informations:

Hunan Yunbang Pharmaceutical Co., Ltd. ( Yunbangpharm) located in Changsha High-tech Industrial Park, Hunan. It is a high-tech enterprise specializing in the research and development, production and sales of Pharmaceutical raw materials, Pharmaceutical intermediates(API) and Fine chemicals. Based in China, Yunbangpharm has been providing suitable solutions for many domestic,foreign pharmaceutical companies and traders. Excellent quality, good reputation and authentic price have won the praise of the majority of customers.
The company adheres to the corporate tenet of "We do not produce medicines, but help pharmaceutical companies make good medicines".

We can provide customers with customized processing, research and development services;
We can develop high-end Pharmaceutical and chemical products with high technical difficulties,high barriers and unique production processes;
We can provide 100 grams Grade, kilograms, and hundred kilograms of raw material pharmaceutical intermediates and other products.
We can perform -100°C to 300°C reaction.

R&D strength is the company's core competitiveness.Yunbangpharm has maintains a good cooperation relationship with many Universities and Research institutes locally, which can quickly transform R&D results into industrial production.

Our goal : To achieve the integrated upgrade of P harmaceutical intermediates, raw materials and high-end chemical products, adhere to "serving pharmaceutical companies, creating our brands" to provide customers with high-quality and low-cost pharmaceutical and chemical products, realizing Win-win cooperation and common development.

 

Organic Intermediate

PNEUTEC.IT, 2023