N-acetylglucosamine (also known as N-acetyl glucosamine) is a simple sugar derived from the outer shell of crustaceans. Chemically similar to
glucosamine
, a natural substance found in
cartilage
, N-acetylglucosamine is thought to alleviate joint stiffness and pain, protect the lining of the stomach and intestines, and reduce dark spots on the skin caused by sun exposure and aging.
Available in capsule, tablet, powder, cream, and serum formulations, N-acetylglucosamine is one of three supplemental forms of glucosamine alongside glucosamine sulfate and glucosamine hydrochloride. Despite their similarities, these are not considered interchangeable.
The effects of glucosamine appeared to increase when combined with chondroitin. In total, 79% of those who received both supplements reported a significant reduction in pain compared to 54% of the control group who received just a
placebo.
N-acetylglucosamine may help reduce the severity and recurrence of IBD, suggests a 2023 study published in the journal
PNAS.
N-acetylglucosamine has long been touted for its skin-lightening properties by many cosmetic and skincare manufacturers.
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