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Pharmaceutical Intermediate
Wuhan Hhd Supply Pharmaceutical Grade Valaciclovir HCl Antiviral Valaciclovir Hydrochloride Purity Valaciclovir
Model NO.
Valaciclovir Hydrochloride
Grade
Pharmaceutical Grade
Color
White
Transport Package
Alumininum Foli Bags
Specification
10g, 50g, 200g, 1kg, 5kg
Trademark
hhdpharm
Origin
China
Reference Price
Please contact us for quote
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Description
Product Description
Wuhan HHD Pharm Supply
High Quality Antiviral Raw Material Ganciclovir Powder CAS 82410-32-0
product name
Vidarabine
cas number
124832-26-4
apperance
White powder
Density
1.5±0.1 g/cm3
MF
C
13
H
20
N
6
O
4
MW
324.336
Valacyclovir (Valacyclovir) is a guanine analogue antiviral drug, which is clinically used for the treatment of herpes simplex and herpes zoster infections. It is a prodrug of acyclovir and can be converted into acyclovir in the body.
Valacyclovir hydrochloride, an orally active L-valyl ester of the potent antiviral agent aciclovir, was launched in 1995 in the United Kingdom for the treatment of herpes simplex virus (HSV) infections of the skin and mucous membranes, including initial and recurrent enital herpes. As a prodrug, valaciclovir has an improved pharmacokinetic profile to aciclovir. It is rapidly absorbed after oral administration and extensively converted to aciclovir via first-pass metabolism to achieve plasma levels of aciclovir comparable to those seen with aciclovir via i.v. route. Valacyclovir is then activated selectively in virus-infected cells by viral thymidine kinase to form aciclovir triphosphate in a stepwise fashion. This active species inhibits viral DNA polymerase via irreversible binding to the active site of the enzyme. Once aciclovir is incorporated into the elongating viral DNA, it terminates replication of the viral DNA strand, an antiviral mechanism unique to aciclovir. Valacyclovir is reportedly in clinical trials for the suppression of cytomegalovirus infection and disease in renal transplant patients.
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