China Price Pure Everolimus 99% CAS 159351-69-6 Everolimus Powder
Product Description
China Price Pure Everolimus 99% CAS 159351-69-6 Everolimus Powder
| Product name | China Price Pure Everolimus 99% CAS 159351-69-6 Everolimus Powder |
| CAS No. | 159351-69-6 |
| Einecs No | N/A |
| Appearance | white powder |
| Storage Temperature | Keep in a cool, dry, dark location in a tightly sealed container or cylinder. |
Solubility:Soluble in ,, DMSO (100mg/ml), water (<1mg/ml, 25c), ethanol (100mg/ml)
Usage:Animal Pharmaceuticals
Everolimus, an orally adminstered rapamycin analog, has recently been approved by the FDA for treatment of renal cell
carcinoma (RCC) refractory to inhibitors of vascular endothelial () receptor signaling. Everolimus
significantly increased progression-free survival (median PFS for the everolimus treated group was 4.0 months versus
1.9 months for the placebo group), although tumor regressions were observed only infrequently.
While the target for everolimus, (the serine/threonine kinase mTOR) is well established, the mechanism by which this
agent retards tumor growth is not well defined. Further, biomarkers that predict tumor sensitivity are still elusive. The
mechanism of action, preclinical antitumor activity, and clinical activity of everolimus against RCC are reviewed.
Function of
Everolimus
Everolimus may have a role in heart transplantation, as it has been shown to reduce chronic allograft vasculopathy in
such transplants. It also may have a similar role to sirolimus in kidney and other transplants.
Although, sirolimus had generated fears over use of m-TOR inhibitors in liver transplantation recipients, due to possible
early hepatic artery thrombosis and graft loss, use of everolimus in the setting of liver transplantation is promising. Jeng
et al., in their study of 43 patients, concluded the safety of everolimus in the early phase after living donor liver
transplantation. In their study, no hepatic artery thrombosis or wound infection was noted. Also, a possible role of
everolimus in reducing the recurrence of hepatocellular carcinoma after liver transplantation was correlated. A target
trough level of 3 ng/mL at 3 months was shown to be beneficial in recipients with pre-transplant renal dysfunction. In
their study, 6 of 9 renal failure patients showed significant recovery of renal function, whereas 3 showed further
deterioration, one of whom required hemodialysis.
Pharmaceutical Intermediate
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