CAS 5985- 28 -4 Synephrine Hydrochloride a α -Adrenergic Receptor Agonist, Vasoconstrictor.

Model NO.
5985-28-4
Storage Temp
+25ºC
Capacity
1000kg/Mon
Transport Package
25kg/Drum/1000g/Bag/10g/Bag
Specification
100% raw material
Trademark
Widely
Origin
China
Production Capacity
1000kg/Mon
Reference Price
$ 13.50 - 45.00
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Product Description

CAS 5985-28-4 Synephrine Hydrochloride a α -Adrenergic Receptor Agonist, Vasoconstrictor.
CAS 5985-28-4 Synephrine Hydrochloride a α -Adrenergic Receptor Agonist, Vasoconstrictor.
Description (±)-Synephrine is an alkaloid with vasoconstrictor and metabolic activities. It binds to α 1A -, α 2A -, and α 2C -adrenergic receptors (ARs; K i s = 78, 36.7, and 24.4 μM, respectively). (±)-Synephrine is an agonist of α 1A -ARs in HEK293 cells (EC 50  = 4 μM in a reporter assay) but not in CHO cells expressing α 2A - or α 2C -AR. It also acts as an antagonist of α 1A -, α 2A -, and α 2C -ARs, inhibiting L-phenylephrine-induced activation of α 1A -AR in HEK293 cells and activation of α 2A - and α 2C -ARs induced by the α 2 -AR agonist medetomidine in CHO cells (IC 50 s = 12.8, 26, and 27.3 μM, respectively, in reporter assays). (±)-Synephrine induces contractions in isolated rabbit aortic rings (EC 50  = 6.2 μg/ml) and increases ligation-induced mean arterial pressure in rats when administered at a dose of 2 mg/kg per day. It induces lipolysis in isolated rat and human adipocytes when used at concentrations of 100 and 1,000 μg/ml. (±)-Synephrine (50 μM) increases phosphorylation of Akt and AMP-activated protein kinase (AMPK) and translocation of Glut4 to the plasma membrane, as well as increases insulin-induced glucose consumption in L6 muscle cells when used at concentrations ranging from 25 to 200 μM.
Chemical Properties Pale Beige Solid
Uses A α-adrenergic receptor agonist, vasoconstrictor.
CAS 5985-28-4 Synephrine Hydrochloride a α -Adrenergic Receptor Agonist, Vasoconstrictor.
CAS 5985-28-4 Synephrine Hydrochloride a α -Adrenergic Receptor Agonist, Vasoconstrictor.
Hubei weideli Chemical Reagent Co., Ltd., located in Wuhan East Lake New Technology Development Zone, is a manufacturing supplier focusing on reagent products for scientific research, and its business scope includes the manufacturing of special chemical products; Disinfectant production; Sales of special chemical products; Disinfectant sales; Research and development of biological feed; Research and development of bio based materials technology; Research and development of biochemical products technology; Technical services, technical development, technical consultation, technical exchange, technology transfer and technology promotion; Sales of instruments and meters; Sales of daily glass products; Sales of technical glass products; Sales of electronic special materials; Technology import and export; Import and export of goods; Veterinary drug management; Production of disinfection products for the prevention and treatment of infectious diseases.

The company has gradually established extensive cooperation with scientific research institutions in Colleges and universities and powerful enterprises to lay a solid foundation for technological production; At the same time, we will recruit talents all over the country and keep them fresh and energetic; With more than ten years of experience and accumulation in the industry, the company further improves its market competitiveness and strengthens its support to customers.

With the help of modern ERP system, the company provides customers with accurate quotation and inventory information in time. It has a warehouse base and Laboratory of more than 1000 square meters in Jiangxia District, Wuhan. The system inventory products can be ordered on the same day, and the order number is given on the same day of delivery. The information can be queried online, followed up in real time, and customer service provides after-sales support services.

Hubei weideli Chemical Reagent Co., Ltd. is committed to scientific research.


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