Description
Naproxen (brand names: Aleve, Naprosyn, and many others) is a nonsteroidal anti-inflammatory drug (NSAID) of the propionic acid class (the same class as ibuprofen) that relieves pain, fever, swelling, and stiffness.:665,673 It is a nonselective COX inhibitor, usually sold as the sodium salt.
It is the preferred NSAID for long-term use in people with a high risk of cardiovascular complications (for example, heart attacks or strokes),:665 due to its relatively low risk of such complications. Naproxen poses an intermediate risk of stomach ulcers compared to ibuprofen, which is low-risk, and indometacin, which is high-risk. To reduce stomach ulceration risk, it is often combined with a proton-pump inhibitor (a medication that reduces stomach acid production) during long-term treatment of those with pre-existing stomach ulcers or a history of developing stomach ulcers while on NSAIDs.:665,673
Basic Info
Chemical Name
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Naproxen
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Synonyms
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(2S)-2-(6-methoxynaphthalen-2-yl)propanoic acid;(S)-(+)-6-Methoxy-α-methyl-2-naphthaleneacetic Acid;NAPROXEN;(S)-(+)-2-(6-Methoxy-2-naphthyl)propionic Acid;Naproxene;Expand
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CAS No.
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22204-53-1
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Molecular Formula
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C14H14O3
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Molecular Weight
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230.25900
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PSA
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46.53000
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LogP
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3.03650
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Properties
Appearance & Physical State
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white powder
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Density
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1.197g/cm3
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Boiling Point
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403.9ºC at 760mmHg
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Melting Point
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153-154ºC
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Flash Point
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154.5ºC
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Refractive Index
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67.5 ° (C=1, CHCl3)
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Storage Condition
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Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
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Vapor Pressure
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3.01E-07mmHg at 25°C
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