Hot Sale Rosiglitazone Maleate CAS 155141-29-0 for Antidiabetic

Hot Sale Rosiglitazone Maleate CAS 155141-29-0 For Antidiabetic

Product Name:    Metadoxine
Synonyms:    METADOXINE;Metadoxil;Metadoxine(Pyridoxine Pyroglutamate);METADOXINE(FORR&DONLY);5-Hydroxy-6-methyl-3,4-pyridinedimethano l, 5-Oxo-L-proline;Metasin;5-oxo-l-proline compound with 5-hydroxy-6-methylpyridine-3,4-dimethano l (1:1);Metadoxin
CAS:    74536-44-0
MF:    C8H11NO3.C5H7NO3
MW:    298.293
EINECS:    277-913-8
Product Categories:    Aromatics Compounds;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File:    74536-44-0.mol


Rosiglitazone maleate, belongs to a novel class of thiazolidine diones launched for the treatment of non-insul in-dependent diabetes mellitus (NIDDM), a disease characterized by a pancreatic β-cell defect and insul in resistance in the liver and peripheral tissues. The racemic base can be obtained by KnSvenagel condensation between 2, 4-thiazolidinedione and the corresponding 4-substituted benzaldehyde (itself prepared in 2 steps from 2-chloropyridin e), followed by reduction of the benzylidene. Rosiglitazone was shown to be a potent agonist of peroxisome proliferator activate d receptor-gamma (PPARgamma), a nuclear receptor involved in the differentiation of adipose tissue, without activating liver PPAR-alpha receptors. This activation of PPAR-gamma could mediate the down-regulation of leptin gene expression. In animal models, Rosiglitazone has been shown to normalize glucose metabolism and reduce the exogenous dose of insul in needed to achieve glycemic control. In patients with Type II diabetes, daily doses (4 or 8 mg) of Rosiglitazone significantly improved blood sugar control without affecting cardiac structure or function.

Rosiglitazone Maleate CAS 155141-29-0  of Chemical Properties
Melting point     102-104°C
storage temp.     Sealed in dry,2-8°C
solubility     DMSO (Slightly), Methano l (Slightly)
form     Solid
color     White to Light Yellow
CAS DataBase Reference    74536-44-0(CAS DataBase Reference)
Function and Application of  Rosiglitazone Maleate CAS 155141-29-0

Company Profile
Anhui puya biological technology co.,ltd was established in Hefei. Registered capital is 5 million. It is specialized in manufacture plant extract, API and chemicals raw material powder, food additives and oil. which are applied to skin care, healthcare, weight loss products, sex improvement, and pharmaceuticals. We will uphold honesty and pragmatic, innovative and enterprising service purposes, and provide a variety of quality services to our customers at abroad. It aims at supplying good product and comfort service. The strict quality control is to meet the customer's requirement, to get a highly praised and to be high quality supplier. If you have any question, or need samples, please feel free to contact us.

FAQ
Q1. What's the MOQ?
A: Usually 1 kg.  It is based on the different product. Some are 1g and some are 1 ton. Please be free to consult our salesman.
 
Q2. What's the shipping time?
A: If in stock, we will ship it out immediately.  By FedEx will be 3~5 days to you.
 
Q3. If I need less than the MOQ, is it possible?
A: Yes. Please be free to consult our salesman.
 
Q4. Can you supply the free sample?
A: Usually it is possible. but the shipping cost be paid by customers. It based on the different product. Please be free to consult our salesman.
 
Q5. How to store the product?
A: Store in cool and dry place. It must be in well closed containers. The shelf life will be 2 years.
 
Q6: What's your main payment method?
A: T/T, trade assurance, west union, money gram.
 
Q7: Do you have COA, MSDS, CO, Health certificate, form 9 or other certificate?
A: Yes, we have. pls be free to contact us to get updated one.