Product Description
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Xylazine Basic information
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Product Name:
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Xylazine
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Synonyms:
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2-(2,6-dimethylanilino)-5,6-dihydro-4h-1,3-thiazine;2-(2,6-dimethylphenylamino)-4h-5,6-dihydro-1,3-thiazine;5,6-dihydro-2-(2,6-xylidino)-4h-1,3-thiazine;5,6-dihydro-2-(2,6-xylidino)-4h-3-thiazine;2-(2,6-Dimethylphenylamino)-5,6-dihydro-4H-thiazine;Xylazine Base & HCL;Xylazine,2-(2,6-Dimethylphenylamino)-5,6-dihydro-4H-thiazine hydrochloride;Xylazine (200 mg)
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CAS:
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7361-61-7
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MF:
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C12H16N2S
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MW:
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220.33
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EINECS:
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230-902-1
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Product Categories:
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7361-61-7
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Mol File:
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7361-61-7.mol
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Xylazine Chemical Properties
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Melting point
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140 C
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Boiling point
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334.2±52.0 °C(Predicted)
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density
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1.0905 (rough estimate)
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refractive index
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1.5700 (estimate)
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storage temp.
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-20°C
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solubility
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Solubleat 50mg/ml. Also soluble in dilute acid solutions.
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pka
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7.67±0.20(Predicted)
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form
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Powder
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CAS DataBase Reference
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7361-61-7(CAS DataBase Reference)
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Hazard Codes
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T,Xi
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Risk Statements
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25-36/37/38
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Safety Statements
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45-37/39-26
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RIDADR
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UN 2811 6.1/PG 3
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WGK Germany
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3
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RTECS
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XJ0776300
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HazardClass
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6.1
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HS Code
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2934990002
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Toxicity
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LD50 in mice (mg/kg): 43 i.v.; 121 s.c.; 240 orally; LD50 in rats (mg/kg): 130 orally (Sagner)
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Provider
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Language
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N-(2,6-Dimethylphenyl)-5,6-dihydro-4H-1,3-thiazin-2-amine
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English
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SigmaAldrich
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English
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Xylazine Usage And Synthesis
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Description
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Xylazine is an agonist of α
2
-adrenergic receptors (K
i
= 194 nM). It is an analog of clonidine, an α
2
-adrenergic receptor agonist used to reduce blood pressure. Xylazine is used for sedation, anesthesia, and analgesia in non-human mammals. This product is also available as an analytical reference standard .
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Originator
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Xylazine,Bayer
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Uses
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Antinociceptive;Alpha-2 adrenergic agonist
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Uses
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Xylazine is an α2 class of adrenergic receptor agonist. Xylazine is a clonidine analoque that acts on presynaptic and postsynaptic receptors as an a 2-adrenergic agonist.
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Manufacturing Process
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2,6-Dimethylphenyl isothiocyanate, 31.0 g (0.2 mole), prepared from 2,6- dimethylaniline , were added dropwise during 15 min to a well-stirred suspension of 15.0 g (0.2 mole) of 3-aminopropanol-1 in 100 ml of ether. The ether started to boil. Stirring under reflux was continued for 30 min, and the ether was then distilled off. The residue was treated with 100 ml of concentrated and boiled under reflux for 30 min. After cooling, it was diluted with water, filtered free from impurities, and the base was precipitated by the addition of concentrated solution. When recrystallized from benzene-ligroin, the resulting compound 2-(2,6- dimethyl-phenylamino)-4H-5,6-dihydro-1,3-thiazine, melting point 140-142°C (yield 90% of the theoretical).
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Therapeutic Function
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Analgesic, Anesthetic
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General Description
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Xylazine is soluble (50 mg/ml), yielding a clear, colorless solution. It is also soluble in dilute HCl acid Xylazine is practically insoluble in water and in alkali solutions.
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Biochem/physiol Actions
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Xylazine when used along is considered to be a potent and safe anaesthetic in experimental animal. It is known to elevate the hepatic release of glucose, which aggravates to hyperglycemia.
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Mechanism of action
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Xylazine is marketed as its hydrochloride salt as Rompun (100 mg/mL) and Anased (20 mg/mL) injectable solutions for intravenous administration to horses and dogs, respectively. The actions of xylazine may be reversed by the administration of yohimbine, an indolalkylamine alkaloid, that blocks those α2- adrenoreceptors that are stimulated by xylazine.
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Safety Profile
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Poison by ingestion, subcutaneous, and intravenous routes. Human systemic effects: change in motor activity, fall in blood pressure, miosis, pleural thickening, pulse rate decrease, somnolence. When heated to decomposition it emits very toxic fumes of NOx and SOx.
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Detailed Photos
Company Profile
Founded in 2012, Hanhong Medicine Technology (Hubei) Co., Ltd. is located in Wuhan, Hubei Province, China. The company is a product research and development, production, agent, sales in one of the high-tech enterprise integrating inorganic chemicals, organic chemicals, flavors and fragrances, pharmaceutical raw materials, intermediates and other fine chemical products. The company has established good cooperative relations with a number of inspection and testing institutions and large companies at home and abroad, and has a sound scientific research system and quality certification system. The company enjoys a high reputation at home and abroad in line with the business philosophy of "integrity management, quality control and customer first".
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Our Advantages
1.Quick Response Within 12 hours.
2.Quality Guarantee: All products are strictly tested by our QC, confirmed by QA.
3.Reasonable & Competitive Price
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4.Fast Delivery:Parcel can be sent out in 24 hours after payment tracking number available
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5.We are a professional production leading factory in pharmaceutical area of many years
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FAQ
Q1: Can i get some samples?
A:Yes, we can supply the free sample, but the shipping cost be paid by our customers.
Q2: How to start orders or make payments?
A:Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T, Western Union or Alibaba link.
Q3: How to confirm the Product Quality before placing orders?
A:1.You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples.
2. You can tell us your product specifications and requests,we will manufacture the products according to your requests.
Q4:Is there a discount?
A:Different quantity has different discount.
Q5: How do you treat quality complaint?
A:Our quality control will reduce the quality problem to near zero. If there is a real
quality problem caused by us, we will send you free goods for replacemen
t
.
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