Josamicina 16846-24-5 usata come antibiotico macrolide efficace contro a. Varietà di patogeni

Model No.
16846-24-5
standard
USP/Ep/Bp/Cp/IP/Jp/Who/in-House
capacità
1000 kg/mon
Pacchetto di Trasporto
25kg/Drum/1000g/Bag/10g/Bag
Specifiche
100% raw material
Marchio
Widely
Origine
China
Capacità di Produzione
1000 kg/mon
Prezzo di riferimento
$ 27.00 - 45.00
contattaci

Descrizione del Prodotto

Josamycin 16846-24-5 Used as a Macrolide Antibiotic Effective Against a Variety of Pathogens
 
 
Chemical Properties Josamycin is a macrolide substance having antibacterial activity produced by the growth of Streptomyces narboensis var. josamyceticus.
Josamycin appears as white to yellowish white powder, slightly hygroscopic. Josamycin is very soluble in methanol or in ethanol, and very slightly soluble in water.
Originator Josalid,Biochemie
Uses Josamycin, is used as a macrolide antibiotic effective against a variety of pathogens.
Uses As a 16-membered ring macrolide antibiotic with antimicrobial activity against a wide range of pathogens. Josamycin can be particularly used in the treatment of Mycoplasma infection.
Josamycin is used to study the modification of phagocytosis and cytokine production by macrolide antibiotics, immunomodulatory effects, the suppression of matrix metalloproteinase production as well as study bacteria protein synthesis at the level of the the 23S rRNA, 50S ribosomal subunit.
Definition ChEBI: A macrolide antibiotic produced by certain strains of Streptomyces narbonensis var. josamyceticus.
Manufacturing Process 100 ml of a culture medium consisting of water containing 1.5% soybean meal, 1% starch, 1% glucose, 0.3% sodium chloride, 0.1% dipotassium hydrogen phosphate, and 0.05% magnesium sulfate was placed in a 500 ml flask and sterilized for 20 min at 120°C. After cooling, the culture medium was inoculated with strain A 205-P2 Streptomyces narbonensis var. josatny ceticus, and the strain was subjected to shaking culture at 27°-29°C and at 130 strokes per min and 8 cm amplitude. After 3 days of culture, the culture fluids in such 100 flasks were combined together and filtered to give 8700 ml of culture filtrate. The pH of the filtrate was 6.4 and showed an inhibition zone of 25 mm. to Bacillus subtilis (PCI 219 strain). The filtrate was extracted with 8700 ml of ethyl acetate. The extract (7300 ml) thus obtained was concentrated to 730 ml under vacuum at temperatures lower than 50°C, 360 ml of water added, and then concentrated hydrochloric acid added to ad just the pH to 2.0, whereby josamycin was transferred to the aqueous layer. After adjusting the pH of the aqueous layer to 7.5 by the addition of 0.1 N sodium hydroxide, josamycin was extracted with 180 ml of ethyl acetate.
Josamycin was then transferred to 90 ml of an aqueous solution at pH 2.0 and extracted again with 45 ml of ethyl acetate as above process. Ethyl acetate solution thus obtained was evaporated under reduced pressure to give a solidified product, which was dissolved in 5 ml of benzene to remove impurities and the product, solidified from the benzene solution by evaporating under reduced pressure, was dissolved in a small amount of ethyl acetate and subjected to an alumina chromatography. That is, Brockman alumina (Merck) was treated with hydrochloric acid, sufficiently rinsed with water, and activated by heating for 5 h at 150°C.
50.0 g of thus treated alumina was filled in a glass tube of 1.6 cm in diameter by using ethyl acetate. The above prepared ethyl acetate solution was added to the alumina column and the product was eluted with 200 ml of ethyl acetate. The eluate thus obtained was concentrated under reduced pressure and the solid product thus obtained was dissolved in 5 ml of benzene and 50 ml of n-hexane added to give 0.18 g of amorphous josamycin having a purity of above 90%.
Therapeutic Function Antibiotic
Pharmaceutical Applications A naturally occurring antibiotic produced by Streptomyces narbonensis var. josamyceticus and belonging to the leucomycin group of macrolides. It is formulated for oral administration.
Many Gram-positive and Gram-negative anaerobes are susceptible, including Peptostreptococcus spp., Propionibacterium spp., Eubacterium spp. and Bacteroides spp.
After a single 1 g oral dose, a peak serum concentration of 2.74 mg/L was achieved 0.75 h after dosing. The AUC was 4.2 mg.h/L, and the apparent elimination half-life 1.5 h. Several inactive metabolites could be detected. It penetrates into saliva, tears and sweat, and achieves high levels in bile and lungs. It is mostly metabolized and excreted in the bile in an inactive form. Less than 20% of the dose appears in the urine, producing levels of around 50 mg/L.
The drug is generally well tolerated, producing only mild gastrointestinal disturbance. Its uses are similar to those of erythromycin. It is of limited availability.
Biological Activity Josamycin inhibits bacterial protein biosynthesis by inhibiting peptidyltransferase and ribosomal translocation, and depleting the intracellular pools of aminoacyl-tRNAs available for protein synthesis by drop-off and incomplete peptidyl-tRNA hydrolase activity. It slows down formation of the first peptide bond of a nascent peptide in an amino acid-dependent way and inhibits formation of the second or third peptide bond.
Josamycin 16846-24-5 Used as a Macrolide Antibiotic Effective Against a Variety of Pathogens
Josamycin 16846-24-5 Used as a Macrolide Antibiotic Effective Against a Variety of Pathogens
Hubei weideli Chemical Reagent Co., Ltd., located in Wuhan East Lake New Technology Development Zone, is a manufacturing supplier focusing on reagent products for scientific research, and its business scope includes the manufacturing of special chemical products; Disinfectant production; Sales of special chemical products; Disinfectant sales; Research and development of biological feed; Research and development of bio based materials technology; Research and development of biochemical products technology; Technical services, technical development, technical consultation, technical exchange, technology transfer and technology promotion; Sales of instruments and meters; Sales of daily glass products; Sales of technical glass products; Sales of electronic special materials; Technology import and export; Import and export of goods; Veterinary drug management; Production of disinfection products for the prevention and treatment of infectious diseases.

The company has gradually established extensive cooperation with scientific research institutions in Colleges and universities and powerful enterprises to lay a solid foundation for technological production; At the same time, we will recruit talents all over the country and keep them fresh and energetic; With more than ten years of experience and accumulation in the industry, the company further improves its market competitiveness and strengthens its support to customers.

With the help of modern ERP system, the company provides customers with accurate quotation and inventory information in time. It has a warehouse base and Laboratory of more than 1000 square meters in Jiangxia District, Wuhan. The system inventory products can be ordered on the same day, and the order number is given on the same day of delivery. The information can be queried online, followed up in real time, and customer service provides after-sales support services.

Hubei weideli Chemical Reagent Co., Ltd. is committed to scientific research.


I. Do you always have this products in stock?
Our company has more than 1000 kinds of products in stock. We usually have them 
in stock. We can show you the information, forms or pictures of our warehouse 
at any time. If the stock is insufficient, our company will replenish them as 
soon as possible according to the ERP system.

2. What certificates and documents do you offer?
According to the situation of products, we can provide COA, NMR, LC, MS, 
synthesis process, MQA, MSDS, etc

3. Why should I choose you?
Stock in stock and deliver in time
Reasonable price
Product technology and data support
Professional sales team
Perfect pre-sale and after-sale service

4. Can I get best price from you?
We don* t pursue expensive profits
We always try to give best offer
You can also enjoy fun of bargaining

5. How should I pay?
T/T bank transfer West union PayPal

 

Altri Medicine

PNEUTEC.IT, 2023